Oral hydration solutions in experimental osmotic diarrhea: Enhancement by alanine and other amino acids and oligopeptides

R. A. Wapnir, Martin Zdanowicz, S. Teichberg, F. Lifshitz

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Improvement of sodium absorption during the administration of oral hydration solutions (OHS) could increase the efficacy of formulations used in the treatment of infantile diarrhea. To test this hypothesis, selected protein breakdown products were evaluated as absorption enhancers in OHS of different osmolalities and Na-to-glucose ratios in an animal model of osmotic diarrhea induced by cathartics. A very significant increase in water and Na absorption occurred in rats with diarrhea when they were perfused with a 90-mmol/L-Na, 111-mmol/L-glucose OHS containing 30 mmol/L of L-alanine (Ala). The same effect on Na retention was observed with a protein hydrolysate (PrH) in rats with diarrhea. Glycine was not effective. Other experimental OHS were ineffective in rats with diarrhea. The data indicate that in this animal model of chronic diarrhea Na transport enhancers, such as Ala and a PrH, are most efficacious in the presence of higher Na concentration.

Original languageEnglish (US)
Pages (from-to)84-90
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume48
Issue number1
StatePublished - 1988
Externally publishedYes

Fingerprint

oligopeptides
Oligopeptides
Alanine
alanine
Diarrhea
diarrhea
mouth
Amino Acids
amino acids
Protein Hydrolysates
protein hydrolysates
Animal Models
Infantile Diarrhea
Cathartics
rats
Glucose
animal models
glucose
Osmolar Concentration
Glycine

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Oral hydration solutions in experimental osmotic diarrhea : Enhancement by alanine and other amino acids and oligopeptides. / Wapnir, R. A.; Zdanowicz, Martin; Teichberg, S.; Lifshitz, F.

In: American Journal of Clinical Nutrition, Vol. 48, No. 1, 1988, p. 84-90.

Research output: Contribution to journalArticle

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