TY - JOUR
T1 - Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury
AU - Jacobs, Patrick L.
AU - Mahoney, Edward T.
AU - Cohn, Kelly A.
AU - Sheradsky, Laurey F.
AU - Green, Barth A.
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Objective: To examine the effects of short-term creatine monohydrate supplementation on the upper extremity work capacity of persons with cervical-level spinal cord injury (SCI). Design: Randomized, double-blind, placebo-controlled, crossover design study. Consists of 2 treatment phases lasting for 7 days, separated by a 21-day washout period. Setting: University research laboratory trial. Participants: Sixteen men with complete cervical-level SCI (C5-7). Intervention: Subjects were randomly assigned to I of 2 groups and received either 20g/d of creatine monohydrate supplement powder or placebo maltodextrin powder for the first treatment phase; the treatment was reversed in the second phase. Incremental peak arm ergometry tests, using 2-minute work stages and 1-minute recovery periods, were performed immediately before and after each treatment phase (total of 4 assessments). The initial stage was performed unloaded, with power output progressively increased 10 watts/stage until subjects had achieved volitional exhaustion. Main Outcome Measures: Peak power output, time to fatigue, heart rate, and metabolic measurements, including oxygen uptake (Vo2), minute ventilation, tidal volume (VT), and respiration frequency. Results: Significantly greater values of Vo2, Vco2 and VT at peak effort after creatine supplementation (P < .001). Conclusions: Creatine supplementation enhances the exercise capacity in persons with complete cervical-level SCI and may promote greater exercise training benefits.
AB - Objective: To examine the effects of short-term creatine monohydrate supplementation on the upper extremity work capacity of persons with cervical-level spinal cord injury (SCI). Design: Randomized, double-blind, placebo-controlled, crossover design study. Consists of 2 treatment phases lasting for 7 days, separated by a 21-day washout period. Setting: University research laboratory trial. Participants: Sixteen men with complete cervical-level SCI (C5-7). Intervention: Subjects were randomly assigned to I of 2 groups and received either 20g/d of creatine monohydrate supplement powder or placebo maltodextrin powder for the first treatment phase; the treatment was reversed in the second phase. Incremental peak arm ergometry tests, using 2-minute work stages and 1-minute recovery periods, were performed immediately before and after each treatment phase (total of 4 assessments). The initial stage was performed unloaded, with power output progressively increased 10 watts/stage until subjects had achieved volitional exhaustion. Main Outcome Measures: Peak power output, time to fatigue, heart rate, and metabolic measurements, including oxygen uptake (Vo2), minute ventilation, tidal volume (VT), and respiration frequency. Results: Significantly greater values of Vo2, Vco2 and VT at peak effort after creatine supplementation (P < .001). Conclusions: Creatine supplementation enhances the exercise capacity in persons with complete cervical-level SCI and may promote greater exercise training benefits.
KW - Creatine
KW - Dietary supplementation
KW - Exercise tolerance
KW - Rehabilitation
KW - Spinal cord injuries
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U2 - 10.1053/apmr.2002.26829
DO - 10.1053/apmr.2002.26829
M3 - Article
C2 - 11782827
AN - SCOPUS:0036142663
VL - 83
SP - 19
EP - 23
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
SN - 0003-9993
IS - 1
ER -