Abstract
Background: Despite many prospective randomized studies defining the benefits of anticoagulation in atrial fibrillation (AF), there have been no adequate studies in cardiomyopathy (CM) in sinus rhythm. Methods: We review the current knowledge of the risk of stroke in CM, left ventricular systolic dysfunction and heart failure as well as the indications for antithrombotic agents and compare this with AF. Results: The current knowledge of risk factors for stroke and indications for antithrombotic agents in CM is similar to that of AF prior to the treatment studies of the 1980s-1990s. Conclusion: Prospective randomized trial data are urgently needed to determine the role of antithrombotic drugs in CM.
| Original language | English |
|---|---|
| Pages (from-to) | 322-327 |
| Number of pages | 6 |
| Journal | Cerebrovascular Diseases |
| Volume | 26 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1 2008 |
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Keywords
- Atrial fibrillation
- Heart failure, anticoagulation
- Stroke
ASJC Scopus subject areas
- Clinical Neurology
Cite this
Oral anticoagulation in patients with cardiomyopathy or heart failure in sinus rhythm. / Pullicino, P.; Thompson, J. L P; Mohr, J. P.; Sacco, Ralph L; Freudenberger, R.; Levin, B.; Homma, S.
In: Cerebrovascular Diseases, Vol. 26, No. 3, 01.09.2008, p. 322-327.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oral anticoagulation in patients with cardiomyopathy or heart failure in sinus rhythm
AU - Pullicino, P.
AU - Thompson, J. L P
AU - Mohr, J. P.
AU - Sacco, Ralph L
AU - Freudenberger, R.
AU - Levin, B.
AU - Homma, S.
PY - 2008/9/1
Y1 - 2008/9/1
N2 - Background: Despite many prospective randomized studies defining the benefits of anticoagulation in atrial fibrillation (AF), there have been no adequate studies in cardiomyopathy (CM) in sinus rhythm. Methods: We review the current knowledge of the risk of stroke in CM, left ventricular systolic dysfunction and heart failure as well as the indications for antithrombotic agents and compare this with AF. Results: The current knowledge of risk factors for stroke and indications for antithrombotic agents in CM is similar to that of AF prior to the treatment studies of the 1980s-1990s. Conclusion: Prospective randomized trial data are urgently needed to determine the role of antithrombotic drugs in CM.
AB - Background: Despite many prospective randomized studies defining the benefits of anticoagulation in atrial fibrillation (AF), there have been no adequate studies in cardiomyopathy (CM) in sinus rhythm. Methods: We review the current knowledge of the risk of stroke in CM, left ventricular systolic dysfunction and heart failure as well as the indications for antithrombotic agents and compare this with AF. Results: The current knowledge of risk factors for stroke and indications for antithrombotic agents in CM is similar to that of AF prior to the treatment studies of the 1980s-1990s. Conclusion: Prospective randomized trial data are urgently needed to determine the role of antithrombotic drugs in CM.
KW - Atrial fibrillation
KW - Heart failure, anticoagulation
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=48049116412&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48049116412&partnerID=8YFLogxK
U2 - 10.1159/000149581
DO - 10.1159/000149581
M3 - Article
C2 - 18667814
AN - SCOPUS:48049116412
VL - 26
SP - 322
EP - 327
JO - Cerebrovascular Diseases
JF - Cerebrovascular Diseases
SN - 1015-9770
IS - 3
ER -