Oral anticoagulation in patients with cardiomyopathy or heart failure in sinus rhythm

P. Pullicino; J. L.P. Thompson; J. P. Mohr; R. L. Sacco; R. Freudenberger; B. Levin; S. Homma

doi:10.1159/000149581

Oral anticoagulation in patients with cardiomyopathy or heart failure in sinus rhythm

P. Pullicino, J. L.P. Thompson, J. P. Mohr, R. L. Sacco, R. Freudenberger, B. Levin, S. Homma

Neurology

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Background: Despite many prospective randomized studies defining the benefits of anticoagulation in atrial fibrillation (AF), there have been no adequate studies in cardiomyopathy (CM) in sinus rhythm. Methods: We review the current knowledge of the risk of stroke in CM, left ventricular systolic dysfunction and heart failure as well as the indications for antithrombotic agents and compare this with AF. Results: The current knowledge of risk factors for stroke and indications for antithrombotic agents in CM is similar to that of AF prior to the treatment studies of the 1980s-1990s. Conclusion: Prospective randomized trial data are urgently needed to determine the role of antithrombotic drugs in CM.

Original language	English (US)
Pages (from-to)	322-327
Number of pages	6
Journal	Cerebrovascular Diseases
Volume	26
Issue number	3
DOIs	https://doi.org/10.1159/000149581
State	Published - Sep 1 2008

Keywords

Atrial fibrillation
Heart failure, anticoagulation
Stroke

ASJC Scopus subject areas

Clinical Neurology

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title = "Oral anticoagulation in patients with cardiomyopathy or heart failure in sinus rhythm",

abstract = "Background: Despite many prospective randomized studies defining the benefits of anticoagulation in atrial fibrillation (AF), there have been no adequate studies in cardiomyopathy (CM) in sinus rhythm. Methods: We review the current knowledge of the risk of stroke in CM, left ventricular systolic dysfunction and heart failure as well as the indications for antithrombotic agents and compare this with AF. Results: The current knowledge of risk factors for stroke and indications for antithrombotic agents in CM is similar to that of AF prior to the treatment studies of the 1980s-1990s. Conclusion: Prospective randomized trial data are urgently needed to determine the role of antithrombotic drugs in CM.",

keywords = "Atrial fibrillation, Heart failure, anticoagulation, Stroke",

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T1 - Oral anticoagulation in patients with cardiomyopathy or heart failure in sinus rhythm

AU - Pullicino, P.

AU - Thompson, J. L.P.

AU - Mohr, J. P.

AU - Sacco, R. L.

AU - Freudenberger, R.

AU - Levin, B.

AU - Homma, S.

PY - 2008/9/1

Y1 - 2008/9/1

N2 - Background: Despite many prospective randomized studies defining the benefits of anticoagulation in atrial fibrillation (AF), there have been no adequate studies in cardiomyopathy (CM) in sinus rhythm. Methods: We review the current knowledge of the risk of stroke in CM, left ventricular systolic dysfunction and heart failure as well as the indications for antithrombotic agents and compare this with AF. Results: The current knowledge of risk factors for stroke and indications for antithrombotic agents in CM is similar to that of AF prior to the treatment studies of the 1980s-1990s. Conclusion: Prospective randomized trial data are urgently needed to determine the role of antithrombotic drugs in CM.

AB - Background: Despite many prospective randomized studies defining the benefits of anticoagulation in atrial fibrillation (AF), there have been no adequate studies in cardiomyopathy (CM) in sinus rhythm. Methods: We review the current knowledge of the risk of stroke in CM, left ventricular systolic dysfunction and heart failure as well as the indications for antithrombotic agents and compare this with AF. Results: The current knowledge of risk factors for stroke and indications for antithrombotic agents in CM is similar to that of AF prior to the treatment studies of the 1980s-1990s. Conclusion: Prospective randomized trial data are urgently needed to determine the role of antithrombotic drugs in CM.

KW - Atrial fibrillation

KW - Heart failure, anticoagulation

KW - Stroke

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