TY - JOUR
T1 - Oral and extraoral plasmablastic lymphoma
T2 - Similarities and differences in clinicopathologic characteristics
AU - Hansra, Damien
AU - Montague, Naomi
AU - Stefanovic, Alexandra
AU - Akunyili, Ikechukwu
AU - Harzand, Arash
AU - Natkunam, Yasodha
AU - De La Ossa, Margarita
AU - Byrne, Gerald E.
AU - Lossos, Izidore S.
PY - 2010/11
Y1 - 2010/11
N2 - Plasmablastic lymphoma (PBL), initially characterized as an aggressive lymphoma arising in the jaw and oral mucosa in HIV-infected patients, was recently reported to occur with extraoral manifestations, heterogeneous histologic findings, and variable association with immunodeficiency states. We reviewed clinical, morphologic, and immunophenotypic features of 13 cases of PBL to determine whether these different subtypes represent distinct morphologic and clinical entities. Two distinct subtypes of PBL were identified and classified as oral and extraoral PBL. The oral PBLs were strongly associated with HIV infection and commonly demonstrated plasmablastic morphologic features without plasmacytic differentiation. Extraoral PBLs tended to occur in patients with underlying non-HIV-related immunosuppression and universally demonstrated plasmacytic differentiation. The patients with oral PBL demonstrated better overall survival compared with patients with extraoral PBL (P = .02). Our findings suggest that PBL with oral and extraoral manifestation represent 2 distinct clinicopathologic entities.
AB - Plasmablastic lymphoma (PBL), initially characterized as an aggressive lymphoma arising in the jaw and oral mucosa in HIV-infected patients, was recently reported to occur with extraoral manifestations, heterogeneous histologic findings, and variable association with immunodeficiency states. We reviewed clinical, morphologic, and immunophenotypic features of 13 cases of PBL to determine whether these different subtypes represent distinct morphologic and clinical entities. Two distinct subtypes of PBL were identified and classified as oral and extraoral PBL. The oral PBLs were strongly associated with HIV infection and commonly demonstrated plasmablastic morphologic features without plasmacytic differentiation. Extraoral PBLs tended to occur in patients with underlying non-HIV-related immunosuppression and universally demonstrated plasmacytic differentiation. The patients with oral PBL demonstrated better overall survival compared with patients with extraoral PBL (P = .02). Our findings suggest that PBL with oral and extraoral manifestation represent 2 distinct clinicopathologic entities.
KW - Epstein-Barr virus
KW - HIV
KW - Lymphoma
KW - Plasmablastic lymphoma
UR - http://www.scopus.com/inward/record.url?scp=78049502867&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78049502867&partnerID=8YFLogxK
U2 - 10.1309/AJCPJH6KEUSECQLU
DO - 10.1309/AJCPJH6KEUSECQLU
M3 - Article
C2 - 20959653
AN - SCOPUS:78049502867
VL - 134
SP - 710
EP - 719
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 5
ER -
