Oral administration of PCBs induces proinflammatory and prometastatic responses

Sandor Sipka, Sung Yong Eum, Kwang Won Son, Shifen Xu, Vasileios G. Gavalas, Bernhard Hennig, Michal Toborek

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Exposure to specific congeners of polychlorinated biphenyls (PCBs) can induce proinflammatory alterations, which may contribute to the formation of blood-borne tumor metastasis. The main aim of the present study was to establish an experimental model of PCB exposure in which PCBs are administered by oral gavage, which resembles the human exposure through the food chain. To determine structure-function relationship, we studied induction of inflammatory responses in the livers, lungs and brains of mice treated with PCB77 (a major coplanar PCB), PCB104 (a non-coplanar PCB with multiple ortho-chlorine substituents), and PCB153 (a major non-coplanar PCB) after a single gavage dose (150 μmol/kg body weight). The strongest expression of proinflammatory proteins occurred 24 h following the PCB administration independent of the class of PCB congeners. These data indicate that food-chain exposure to PCBs can induce proinflammatory mediators in organs that are potential targets for PCB-induced toxicity.

Original languageEnglish (US)
Pages (from-to)251-259
Number of pages9
JournalEnvironmental Toxicology and Pharmacology
Volume25
Issue number2
DOIs
StatePublished - Mar 1 2008

Keywords

  • Inflammation
  • Polychlorinated biphenyls
  • Tumor metastasis

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Pharmacology

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