Abstract
Exposure to specific congeners of polychlorinated biphenyls (PCBs) can induce proinflammatory alterations, which may contribute to the formation of blood-borne tumor metastasis. The main aim of the present study was to establish an experimental model of PCB exposure in which PCBs are administered by oral gavage, which resembles the human exposure through the food chain. To determine structure-function relationship, we studied induction of inflammatory responses in the livers, lungs and brains of mice treated with PCB77 (a major coplanar PCB), PCB104 (a non-coplanar PCB with multiple ortho-chlorine substituents), and PCB153 (a major non-coplanar PCB) after a single gavage dose (150 μmol/kg body weight). The strongest expression of proinflammatory proteins occurred 24 h following the PCB administration independent of the class of PCB congeners. These data indicate that food-chain exposure to PCBs can induce proinflammatory mediators in organs that are potential targets for PCB-induced toxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 251-259 |
| Number of pages | 9 |
| Journal | Environmental Toxicology and Pharmacology |
| Volume | 25 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1 2008 |
| Externally published | Yes |
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Keywords
- Inflammation
- Polychlorinated biphenyls
- Tumor metastasis
ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis
- Pharmacology
Cite this
Oral administration of PCBs induces proinflammatory and prometastatic responses. / Sipka, Sandor; Eum, Sung Yong; Son, Kwang Won; Xu, Shifen; Gavalas, Vasileios G.; Hennig, Bernhard; Toborek, Michal J.
In: Environmental Toxicology and Pharmacology, Vol. 25, No. 2, 01.03.2008, p. 251-259.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oral administration of PCBs induces proinflammatory and prometastatic responses
AU - Sipka, Sandor
AU - Eum, Sung Yong
AU - Son, Kwang Won
AU - Xu, Shifen
AU - Gavalas, Vasileios G.
AU - Hennig, Bernhard
AU - Toborek, Michal J
PY - 2008/3/1
Y1 - 2008/3/1
N2 - Exposure to specific congeners of polychlorinated biphenyls (PCBs) can induce proinflammatory alterations, which may contribute to the formation of blood-borne tumor metastasis. The main aim of the present study was to establish an experimental model of PCB exposure in which PCBs are administered by oral gavage, which resembles the human exposure through the food chain. To determine structure-function relationship, we studied induction of inflammatory responses in the livers, lungs and brains of mice treated with PCB77 (a major coplanar PCB), PCB104 (a non-coplanar PCB with multiple ortho-chlorine substituents), and PCB153 (a major non-coplanar PCB) after a single gavage dose (150 μmol/kg body weight). The strongest expression of proinflammatory proteins occurred 24 h following the PCB administration independent of the class of PCB congeners. These data indicate that food-chain exposure to PCBs can induce proinflammatory mediators in organs that are potential targets for PCB-induced toxicity.
AB - Exposure to specific congeners of polychlorinated biphenyls (PCBs) can induce proinflammatory alterations, which may contribute to the formation of blood-borne tumor metastasis. The main aim of the present study was to establish an experimental model of PCB exposure in which PCBs are administered by oral gavage, which resembles the human exposure through the food chain. To determine structure-function relationship, we studied induction of inflammatory responses in the livers, lungs and brains of mice treated with PCB77 (a major coplanar PCB), PCB104 (a non-coplanar PCB with multiple ortho-chlorine substituents), and PCB153 (a major non-coplanar PCB) after a single gavage dose (150 μmol/kg body weight). The strongest expression of proinflammatory proteins occurred 24 h following the PCB administration independent of the class of PCB congeners. These data indicate that food-chain exposure to PCBs can induce proinflammatory mediators in organs that are potential targets for PCB-induced toxicity.
KW - Inflammation
KW - Polychlorinated biphenyls
KW - Tumor metastasis
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UR - http://www.scopus.com/inward/citedby.url?scp=38349090551&partnerID=8YFLogxK
U2 - 10.1016/j.etap.2007.10.020
DO - 10.1016/j.etap.2007.10.020
M3 - Article
C2 - 18438459
AN - SCOPUS:38349090551
VL - 25
SP - 251
EP - 259
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
SN - 1382-6689
IS - 2
ER -