Oral acetazolamide as a medical adjuvant to retinal surgery in optic disc pit maculopathy in a pediatric patient

Carla J. Osigian, Daniel Gologorsky, Kara M. Cavuoto, Audina Berrocal, Victor Villegas

Research output: Contribution to journalArticle


Purpose: To describe a novel combination of surgical and medical management for the treatment of optic disc pit maculopathy. Observations: A 12-year-old obese girl with bilateral optic disc pits presented with decreased vision in the left eye (20/400). On dilated fundus examination, she was found to have a macula-involving serous retinal detachment. Pars plana vitrectomy, posterior hyaloid peel, internal limiting membrane peel, fluid-air exchange, temporal juxtapapillary endolaser, and C3F8 tamponade were performed. Postoperatively, there was persistence of subretinal fluid, so oral acetazolamide and a weight loss regimen were started. After 3 months of medical treatment, the subretinal fluid decreased significantly and visual acuity improved to 20/60. Conclusion and Importance: Currently, the mechanisms leading to optic disc pit maculopathy remain a topic of debate. As optic disc pits may provide a conduit between the subarachnoid and subretinal spaces, the reduction of intracranial pressure with the use of systemic carbonic anhydrase inhibitors may play a role in decreasing the subretinal fluid associated with select cases of optic disc pit maculopathy.

Original languageEnglish (US)
Article number100599
JournalAmerican Journal of Ophthalmology Case Reports
StatePublished - Mar 2020



  • Acetazolamide
  • Intracranial pressure
  • Optic disc pit
  • Optical coherence tomography

ASJC Scopus subject areas

  • Ophthalmology

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