Optokinetic nystagmus as a measure of visual function in severely visually impaired patients

Sara Wester, Joseph F. Rizzo, M. David Balkwill, Conrad Wall

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

PURPOSE. To evaluate the efficacy of using optokinetic nystagmus (OKN) as an objective measurement of vision in severely visually impaired patients, in whom it is difficult to measure visual function reliably. Objective visual acuity (VA) measurements would be useful in the pre- and postoperative assessment of severely visually impaired patients who are potential candidates for visual rehabilitation strategies, such as retinal prostheses, neural and stem cell transplantation, and molecular approaches. METHODS. Full-field visual stimuli were used to evoke horizontal OKN responses in 17 subjects. Eye movements were recorded and analyzed to determine the maximum stimulus velocity (Fmax) at which subjects could maintain an OKN response. This endpoint was compared to logMAR VA and Goldmann visual field (VF) test results. RESULTS. Vmax was dependent on VA, VF, and the spatial frequency (SF) of the stimulus, yielding the equation Vmax = 14.2·log(VA) - 6.20·log(SF) + 0.22·VF + 25.0. The findings suggest that V max in the presence of full-field OKN stimuli may provide an objective measure of VA and peripheral vision. CONCLUSIONS. OKN testing may be useful as an additional, more objective means of assessing visual function in a select group of severely visually impaired patients who are being considered as candidates for new visual rehabilitative strategies.

Original languageEnglish
Pages (from-to)4542-4548
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume48
Issue number10
DOIs
StatePublished - Oct 1 2007

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Optokinetic Nystagmus
Visual Acuity
Visual Fields
Visual Prosthesis
Pathologic Nystagmus
Visual Field Tests
Neural Stem Cells
Stem Cell Transplantation
Eye Movements
Rehabilitation

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Optokinetic nystagmus as a measure of visual function in severely visually impaired patients. / Wester, Sara; Rizzo, Joseph F.; Balkwill, M. David; Wall, Conrad.

In: Investigative Ophthalmology and Visual Science, Vol. 48, No. 10, 01.10.2007, p. 4542-4548.

Research output: Contribution to journalArticle

Wester, Sara ; Rizzo, Joseph F. ; Balkwill, M. David ; Wall, Conrad. / Optokinetic nystagmus as a measure of visual function in severely visually impaired patients. In: Investigative Ophthalmology and Visual Science. 2007 ; Vol. 48, No. 10. pp. 4542-4548.
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