Optimizing skin grafting using hair- derived skin grafts

The healing potential of hair follicle pluripotent stem cells

Joshua D. Fox, Katherine L. Baquerizo-Nole, Freya Van Driessche, Elizabeth Yim, Bernard Nusbaum, Francisco Jimenez, Robert Kirsner

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background. A man in his 60s with recurrent venous leg ulcers (VLUs) presented with an 18-month history of a VLU on his medial left leg measuring 59.3 cm2. He had been treated with multi- component compression bandages without significant decrease in ulcer size. Given the ulcergs size, refractory nature, and history of recurrence, the authors sought to optimize the patientgs healing. Methods. Approximately 23% of the total wound was treated using punch grafts (PGs) harvested from different locations on the body based on hair density using the "stick and placeg" method. Results. One month later, a 56% reduction in ulcer size was observed, espe- cially in the area that received hair-bearing skin. Conclusion. Punch grafts from hair-bearing skin are a viable source of follicular stem cells and may be superior to PG from nonhair-bearing skin for the treatment of chronic wounds.

Original languageEnglish (US)
Pages (from-to)109-111
Number of pages3
JournalWounds
Volume28
Issue number4
StatePublished - Apr 1 2016

Fingerprint

Pluripotent Stem Cells
Skin Transplantation
Hair Follicle
Hair
Varicose Ulcer
Leg Ulcer
Transplants
Skin
Ulcer
Compression Bandages
Wounds and Injuries
Leg
Stem Cells
Recurrence
Therapeutics

Keywords

  • hair-derived skin graft
  • punch graft
  • venous leg ulcers

ASJC Scopus subject areas

  • Surgery
  • Medical–Surgical

Cite this

Fox, J. D., Baquerizo-Nole, K. L., Van Driessche, F., Yim, E., Nusbaum, B., Jimenez, F., & Kirsner, R. (2016). Optimizing skin grafting using hair- derived skin grafts: The healing potential of hair follicle pluripotent stem cells. Wounds, 28(4), 109-111.

Optimizing skin grafting using hair- derived skin grafts : The healing potential of hair follicle pluripotent stem cells. / Fox, Joshua D.; Baquerizo-Nole, Katherine L.; Van Driessche, Freya; Yim, Elizabeth; Nusbaum, Bernard; Jimenez, Francisco; Kirsner, Robert.

In: Wounds, Vol. 28, No. 4, 01.04.2016, p. 109-111.

Research output: Contribution to journalArticle

Fox, JD, Baquerizo-Nole, KL, Van Driessche, F, Yim, E, Nusbaum, B, Jimenez, F & Kirsner, R 2016, 'Optimizing skin grafting using hair- derived skin grafts: The healing potential of hair follicle pluripotent stem cells', Wounds, vol. 28, no. 4, pp. 109-111.
Fox JD, Baquerizo-Nole KL, Van Driessche F, Yim E, Nusbaum B, Jimenez F et al. Optimizing skin grafting using hair- derived skin grafts: The healing potential of hair follicle pluripotent stem cells. Wounds. 2016 Apr 1;28(4):109-111.
Fox, Joshua D. ; Baquerizo-Nole, Katherine L. ; Van Driessche, Freya ; Yim, Elizabeth ; Nusbaum, Bernard ; Jimenez, Francisco ; Kirsner, Robert. / Optimizing skin grafting using hair- derived skin grafts : The healing potential of hair follicle pluripotent stem cells. In: Wounds. 2016 ; Vol. 28, No. 4. pp. 109-111.
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