Optimizing antenatal corticosteroid therapy

Matthew W. Kemp, Augusto F. Schmidt, Alan H. Jobe

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Treatment with antenatal corticosteroids (ACS) is standard of care for women at risk of preterm birth between 24 and 34 weeks’ gestation. ACS are increasingly used for other indications, including threated or indicated late preterm birth, elective cesarean, and in at-risk pregnancies for periviable gestations. However, the various drugs and doses being used worldwide have not been rigorously evaluated to optimize clinical responses and to minimize potential risks. Translational research in animal models indicate that a constant, low concentration fetal exposure to ACS is sufficient for lung maturation, resulting in lower fetal exposures. Clinical trials to develop dosing strategies with inexpensive and widely available drugs could promote greater use in low resource environments. “Even the best proven interventions must be evaluated continually through research for their safety, effectiveness, efficacy, accessibility and quality,” Declaration of Helsinki [1].

Original languageEnglish (US)
Pages (from-to)176-181
Number of pages6
JournalSeminars in Fetal and Neonatal Medicine
Issue number3
StatePublished - Jun 2019
Externally publishedYes


  • Betamethasone
  • Dexamethasone
  • Maturation
  • Pharmacology
  • Prematurity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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