Optimal HIV treatment by maximising immune response

Rebecca V. Culshaw, Shigui Ruan, Raymond J. Spiteri

Research output: Contribution to journalArticlepeer-review

163 Scopus citations


We present an optimal control model of drug treatment of the human immunodeficiency virus (HIV). Our model is based upon ordinary differential equations that describe the interaction between HIV and the specific immune response as measured by levels of natural killer cells. We establish stability results for the model. We approach the treatment problem by posing it as an optimal control problem in which we maximise the benefit based on levels of healthy CD4+ T cells and immune response cells, less the systemic cost of chemotherapy. We completely characterise the optimal control and compute a numerical solution of the optimality system via analytic continuation.

Original languageEnglish (US)
Pages (from-to)545-562
Number of pages18
JournalJournal of Mathematical Biology
Issue number5
StatePublished - May 2004


  • Cytotoxic lymphocytes
  • HIV
  • Immune response
  • Numerical methods
  • Optimal control

ASJC Scopus subject areas

  • Modeling and Simulation
  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Mathematics


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