Optimal definitions for abdominal obesity and the metabolic syndrome in Andean Hispanics: The PREVENCION study

Josefina Medina-Lezama, Catherine A. Pastorius, Humberto Zea-Diaz, Antonio Bernabe-Ortiz, Fernando Corrales-Medina, Oscar Leopoldo Morey-Vargas, Diana Andrea Chirinos, Edgar Mũnoz-Atahualpa, Julio Chirinos-Pacheco, Julio Alonso Chirinos

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


OBJECTIVE - We aimed to establish optimal definitions for abdominal obesity and metabolic syndrome (MetS) among Andean adults. RESEARCH DESIGN AND METHODS - Among 1,448 Andean adults, we assessed the relationship between waist circumference and subclinical vascular disease assessed by carotid intima-media thickness (cIMT) and manifest cardiovascular disease (M-CVD). RESULTS - Optimal waist circumference cutoffs to classify individuals with abnormal cIMT or M-CVD were >97 and >87 cm in men and women, respectively. With these cutoffs, there was substantial disagreement between the original American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI) and the recently updated MetS definition, particularly among men (κ = 0.85). Subjects with MetS identified by the updated definition but not meeting the original AHA/NHLBI MetS criteria demonstrated significantly increased cIMT (P < 0.001) compared with subjects who did not meet the MetS criteria by either definition. CONCLUSIONS - Our findings support the use of ethnic-specific waist circumference cutoffs and the updated MetS definition in Andean adults.

Original languageEnglish (US)
Pages (from-to)1385-1388
Number of pages4
JournalDiabetes care
Issue number6
StatePublished - Jun 2010
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing


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