Optical path of infrared neural stimulation in the guinea pig and cat cochlea

Suhrud M Rajguru, Margaret Hwang, Laura E. Moreno, Agnella I. Matic, Stuart R. Stock, Claus Peter Richter

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

It has been demonstrated previously that infrared neural stimulation (INS) can be used to stimulate spiral ganglion cells in the cochlea. With INS, neural stimulation can be achieved without direct contact of the radiation source and the tissue and is spatially well resolved. The presence of fluids or bone between the target structure and the radiation source may lead to absorption or scattering of the radiation and limit the efficacy of INS. To develop INS based cochlear implants, it is critical to determine the beam path of the radiation in the cochlea. In the present study, we utilized noninvasive X-ray microtomography (microCT) to visualize the orientation and location of the optical fiber within the guinea pig and cat cochlea. Overall, the results indicated that the optical fiber was directed towards the spiral ganglion cells in the cochlea and not the nerve fibers in the center of the modiolus. The fiber was approximately 300 μm away from the target structures. In future studies, results from the microCT will be correlated with physiology obtained from recordings in the midbrain.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7883
DOIs
StatePublished - Apr 12 2011
Externally publishedYes
EventPhotonic Therapeutics and Diagnostics VII - San Francisco, CA, United States
Duration: Jan 22 2011Jan 24 2011

Other

OtherPhotonic Therapeutics and Diagnostics VII
CountryUnited States
CitySan Francisco, CA
Period1/22/111/24/11

Fingerprint

guinea pigs
cochlea
cats
Cochlea
optical paths
stimulation
X-Ray Microtomography
Guinea Pigs
Cats
Spiral Ganglion
Infrared radiation
Optical Fibers
Radiation
Radiation Scattering
Optical fibers
radiation sources
Cochlear implants
optical fibers
Cochlear Implants
Fibers

Keywords

  • auditory
  • cat
  • cochlea
  • cochlear implants
  • deafness
  • guinea pig
  • Infrared neural stimulation
  • laser

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Rajguru, S. M., Hwang, M., Moreno, L. E., Matic, A. I., Stock, S. R., & Richter, C. P. (2011). Optical path of infrared neural stimulation in the guinea pig and cat cochlea. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7883). [788357] https://doi.org/10.1117/12.883219

Optical path of infrared neural stimulation in the guinea pig and cat cochlea. / Rajguru, Suhrud M; Hwang, Margaret; Moreno, Laura E.; Matic, Agnella I.; Stock, Stuart R.; Richter, Claus Peter.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883 2011. 788357.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rajguru, SM, Hwang, M, Moreno, LE, Matic, AI, Stock, SR & Richter, CP 2011, Optical path of infrared neural stimulation in the guinea pig and cat cochlea. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7883, 788357, Photonic Therapeutics and Diagnostics VII, San Francisco, CA, United States, 1/22/11. https://doi.org/10.1117/12.883219
Rajguru SM, Hwang M, Moreno LE, Matic AI, Stock SR, Richter CP. Optical path of infrared neural stimulation in the guinea pig and cat cochlea. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883. 2011. 788357 https://doi.org/10.1117/12.883219
Rajguru, Suhrud M ; Hwang, Margaret ; Moreno, Laura E. ; Matic, Agnella I. ; Stock, Stuart R. ; Richter, Claus Peter. / Optical path of infrared neural stimulation in the guinea pig and cat cochlea. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883 2011.
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