Optical Modulation of Azobenzene-Modified Peptide for Gold Surface Binding

Joseph M. Slocik; Zhifeng Kuang; Marc R. Knecht; Rajesh R. Naik

doi:10.1002/cphc.201600670

Optical Modulation of Azobenzene-Modified Peptide for Gold Surface Binding

Joseph M. Slocik, Zhifeng Kuang, Marc R. Knecht, Rajesh R. Naik

Chemistry

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The ability to precisely and remotely modulate reversible binding interactions between biomolecules and abiotic surfaces is appealing for many applications. To achieve this level of control, an azobenzene-based optical switch is added to nanoparticle-binding peptides in order to switch peptide conformation and attenuate binding affinity to gold surfaces via binding and dissociation of peptides.

Original language	English (US)
Pages (from-to)	3252-3259
Number of pages	8
Journal	ChemPhysChem
Volume	17
Issue number	20
DOIs	https://doi.org/10.1002/cphc.201600670
State	Published - Oct 18 2016

Keywords

azobenzene
bionanotechnology
gold nanoparticles
peptides
phage display

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Physical and Theoretical Chemistry

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abstract = "The ability to precisely and remotely modulate reversible binding interactions between biomolecules and abiotic surfaces is appealing for many applications. To achieve this level of control, an azobenzene-based optical switch is added to nanoparticle-binding peptides in order to switch peptide conformation and attenuate binding affinity to gold surfaces via binding and dissociation of peptides.",

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author = "Slocik, {Joseph M.} and Zhifeng Kuang and Knecht, {Marc R.} and Naik, {Rajesh R.}",

note = "Funding Information: We acknowledge Air Force Office of Scientific Research for funding this work (RRN) and AFOSR BRI FA9550-12-1-0266 (MRK). We are grateful to Prof. Andrew Wooley for generously providing BSBCA cross-linker.",

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AU - Slocik, Joseph M.

AU - Kuang, Zhifeng

AU - Knecht, Marc R.

AU - Naik, Rajesh R.

N1 - Funding Information: We acknowledge Air Force Office of Scientific Research for funding this work (RRN) and AFOSR BRI FA9550-12-1-0266 (MRK). We are grateful to Prof. Andrew Wooley for generously providing BSBCA cross-linker.

PY - 2016/10/18

Y1 - 2016/10/18

N2 - The ability to precisely and remotely modulate reversible binding interactions between biomolecules and abiotic surfaces is appealing for many applications. To achieve this level of control, an azobenzene-based optical switch is added to nanoparticle-binding peptides in order to switch peptide conformation and attenuate binding affinity to gold surfaces via binding and dissociation of peptides.

AB - The ability to precisely and remotely modulate reversible binding interactions between biomolecules and abiotic surfaces is appealing for many applications. To achieve this level of control, an azobenzene-based optical switch is added to nanoparticle-binding peptides in order to switch peptide conformation and attenuate binding affinity to gold surfaces via binding and dissociation of peptides.

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KW - bionanotechnology

KW - gold nanoparticles

KW - peptides

KW - phage display

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Optical Modulation of Azobenzene-Modified Peptide for Gold Surface Binding

Abstract

Keywords

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