Optical coherence tomography shows retinal abnormalities associated with optic nerve disease

Kirstin L. Tawse, Thomas R. Hedges, Marisa Gobuty, Carlos Mendoza-Santiesteban

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Optical coherence tomography (OCT) of the macula in patients with primary optic neuropathy has revealed the presence of structural changes in the neurosensory retina in addition to the nerve fibre layer. Subretinal fluid has been documented in papilloedema and non-arteritic ischaemic optic neuropathy, and may account for decreased visual acuity in affected patients. Subretinal fluid has also been described from other causes of optic nerve head swelling including diabetic papillopathy and papillitis. Drugs used in the treatment of multiple sclerosis, such as corticosteroids and fingolimod can cause decreased vision due to central serous and cystoid macular oedema sometimes confused with recurrent optic neuritis. A subset of patients with various types of optic atrophy show microcystic changes in the inner nuclear layer on spectral domain OCT imaging. The pathophysiology and visual signi ficance of these retinal changes remain unclear, but may affect the diagnosis and management of optic nerve disorders.

Original languageEnglish (US)
Pages (from-to)ii30-ii33
JournalBritish Journal of Ophthalmology
Issue numberSUPPL. 2
StatePublished - Jul 2014
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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