Optical coherence tomography of the retina: Applications in neurology

Panitha Jindahra, Thomas R. Hedges, Carlos E. Mendoza-Santiesteban, Gordon T. Plant

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations

Abstract

PURPOSE OF REVIEW: This review summarizes the mechanisms and recent developments of optical coherence tomography and its practical uses in neurology. The application of optical coherence tomography imaging of the retina in multiple sclerosis, neuromyelitis optica, Alzheimer disease, and Parkinson disease are reviewed. RECENT FINDINGS: Thinning of the peripapillary retinal nerve fibre layer has been detected in patients with optic neuritis, multiple sclerosis, neuromyelitis optica, Alzheimer disease, and Parkinson disease. However, the patterns of change differ in some aspects. SUMMARY: The findings indicate loss of retinal ganglion cells and may reflect degenerative change in the brain in these conditions. The retinal nerve fibre layer thickness may be used as a biological marker and may help to distinguish between optic neuritis associated with multiple sclerosis and optic neuritis in neuromyelitis optica.

Original languageEnglish (US)
Pages (from-to)16-23
Number of pages8
JournalCurrent Opinion in Neurology
Volume23
Issue number1
DOIs
StatePublished - Feb 2010
Externally publishedYes

Keywords

  • Alzheimer disease
  • Multiple sclerosis
  • Neuromyelitis optica
  • Optic neuritis
  • Optical coherence tomography
  • Parkinson disease
  • Retinal nerve fibre layer thickness

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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