Optical coherence tomography of the preterm eye: From retinopathy of prematurity to brain development

Adam L. Rothman, Shwetha Mangalesh, Xi Chen, Cynthia A. Toth

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Preterm infants with retinopathy of prematurity are at increased risk of poor neurodevelopmental outcomes. Because the neurosensory retina is an extension of the central nervous system, anatomic abnormalities in the anterior visual pathway often relate to system and central nervous system health. We describe optical coherence tomography as a powerful imaging modality that has recently been adapted to the infant population and provides noninvasive, high-resolution, cross-sectional imaging of the infant eye at the bedside. Optical coherence tomography has increased understanding of normal eye development and has identified several potential biomarkers of brain abnormalities and poorer neurodevelopment.

Original languageEnglish (US)
Pages (from-to)123-133
Number of pages11
JournalEye and Brain
Volume8
DOIs
StatePublished - May 27 2016
Externally publishedYes

Keywords

  • Biomarkers
  • Brain development
  • Neurosensory retina
  • Optical coherence tomography
  • Preterm infant
  • Retinopathy

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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