Optical coherence tomography (OCT) of collagen in normal skin and skin fibrosis

Olubukola Babalola, Andrew Mamalis, Hadar Lev-Tov, Jared Jagdeo

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Optical coherence tomography (OCT) is a non-invasive imaging modality that is transforming clinical diagnosis in dermatology and other medical fields. OCT provides a cross-sectional evaluation of the epidermis and dermis and allows in vivo imaging of skin collagen. Upregulated collagen content is a key feature of fibrotic skin diseases. These diseases are often managed by the practitioner's subjective assessment of disease severity and response to therapies. The purpose of this review is to provide an overview of the principles of OCT and present available evidence on the ability of OCT to image skin collagen in vivo for the diagnosis and management of diseases characterized by skin fibrosis. We review OCT studies that characterize the collagen content in normal skin and fibrotic skin diseases including systemic sclerosis and hypertrophic scars secondary to burn, trauma, and other injury. We also highlight several limitations of OCT and suggest enhancements to improve OCT imaging of skin fibrosis. We conclude that OCT imaging has the potential to serve as an objective, non-invasive measure of collagen's status and disease progression for use in both research trials and clinical practice. The future use of OCT imaging as a quantitative imaging biomarker of fibrosis will help identify fibrosis and facilitate clinical examination in monitoring response to treatment longitudinally without relying on serial biopsies. The use of OCT technology for quantification of fibrosis is in the formative stages and we foresee tremendous growth potential, similar to the ultrasound development paradigm that evolved over the past 30 years.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalArchives of Dermatological Research
Volume306
Issue number1
DOIs
StatePublished - Jan 14 2014
Externally publishedYes

Fingerprint

Optical Coherence Tomography
Fibrosis
Collagen
Skin
Skin Diseases
Hypertrophic Cicatrix
Collagen Diseases
Systemic Scleroderma
Wounds and Injuries
Dermis
Disease Management
Dermatology
Epidermis
Disease Progression
Biomarkers
Clinical Trials
Technology
Biopsy

Keywords

  • Collagen
  • Optical coherence tomography (OCT)
  • Skin fibrosis
  • Skin imaging

ASJC Scopus subject areas

  • Dermatology

Cite this

Optical coherence tomography (OCT) of collagen in normal skin and skin fibrosis. / Babalola, Olubukola; Mamalis, Andrew; Lev-Tov, Hadar; Jagdeo, Jared.

In: Archives of Dermatological Research, Vol. 306, No. 1, 14.01.2014, p. 1-9.

Research output: Contribution to journalReview article

Babalola, Olubukola ; Mamalis, Andrew ; Lev-Tov, Hadar ; Jagdeo, Jared. / Optical coherence tomography (OCT) of collagen in normal skin and skin fibrosis. In: Archives of Dermatological Research. 2014 ; Vol. 306, No. 1. pp. 1-9.
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