OPMI: The ontology of precision medicine and investigation and its support for clinical data and metadata representation and analysis

The Kidney Precision Medicine Project Consortium

Research output: Contribution to journalConference articlepeer-review

Abstract

Consortia conducting precision medicine studies face a major challenge of integrating big data including clinical and biomedical data. In this study, we report our development of the community-driven Ontology of Precision Medicine and Investigation (OPMI) and its applications in clinical data and metadata representation. OPMI has been used to represent the common data model (CDM) of the Observational Health Data Sciences and Informatics (or OHDSI) program. It has also been used to represent approximately 30 case report forms defined by the NIH-supported Kidney Precision Medicine Project (KPMP). Our case studies showed that OPMI is able to semantically and precisely represent the OHDSI CDM, various KPMP clinical forms, and their associated data and metadata. Such ontological representations support standardized data representation, sharing, recording, integration, and advanced analysis.

Original languageEnglish (US)
JournalCEUR Workshop Proceedings
Volume2931
StatePublished - 2019
Externally publishedYes
Event10th International Conference on Biomedical Ontology, ICBO 2019 - Buffalo, United States
Duration: Jul 30 2019Aug 2 2019

Keywords

  • Case report form
  • Common data model
  • Kidney

ASJC Scopus subject areas

  • Computer Science(all)

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