Opioids and the skin: "Itchy" perspectives beyond analgesia and abuse

Martin Schmelz; Ralf Paus

doi:10.1038/sj.jid.5700634

Opioids and the skin: "Itchy" perspectives beyond analgesia and abuse

Martin Schmelz, Ralf Paus

Research output: Contribution to journal › Comment/debate › peer-review

9 Scopus citations

Abstract

Opioids are intimately linked to central pain inhibition and their abuse potential. Thus, peripheral opioid receptors in the skin have been studied initially with a focus on their peripheral analgesic properties. Recent results, however, clearly indicate that opioids play a specific role in skin homeostasis by modulating keratinocyte differentiation, wound healing, and inflammatory responses.

Original language	English (US)
Pages (from-to)	1287-1289
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	127
Issue number	6
DOIs	https://doi.org/10.1038/sj.jid.5700634
State	Published - Jun 2007
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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10.1038/sj.jid.5700634

Cite this

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abstract = "Opioids are intimately linked to central pain inhibition and their abuse potential. Thus, peripheral opioid receptors in the skin have been studied initially with a focus on their peripheral analgesic properties. Recent results, however, clearly indicate that opioids play a specific role in skin homeostasis by modulating keratinocyte differentiation, wound healing, and inflammatory responses.",

author = "Martin Schmelz and Ralf Paus",

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AB - Opioids are intimately linked to central pain inhibition and their abuse potential. Thus, peripheral opioid receptors in the skin have been studied initially with a focus on their peripheral analgesic properties. Recent results, however, clearly indicate that opioids play a specific role in skin homeostasis by modulating keratinocyte differentiation, wound healing, and inflammatory responses.

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Opioids and the skin: "Itchy" perspectives beyond analgesia and abuse

Abstract

ASJC Scopus subject areas

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