Opioid Use, Gut Dysbiosis, Inflammation, and the Nervous System

Richa Jalodia, Yaa Fosuah Abu, Mark Ryan Oppenheimer, Bridget Herlihy, Jingjing Meng, Irina Chupikova, Junyi Tao, Nillu Ghosh, Rajib Kumar Dutta, Udhghatri Kolli, Yan Yan, Eridania Valdes, Madhulika Sharma, Umakant Sharma, Shamsudheen Moidunny, Sabita Roy

Research output: Contribution to journalReview articlepeer-review


Opioid use disorder (OUD) is defined as the chronic use or misuse of prescribed or illicitly obtained opioids and is characterized by clinically significant impairment. The etiology of OUD is multifactorial as it is influenced by genetics, environmental factors, stress response and behavior. Given the profound role of the gut microbiome in health and disease states, in recent years there has been a growing interest to explore interactions between the gut microbiome and the central nervous system as a causal link and potential therapeutic source for OUD. This review describes the role of the gut microbiome and opioid-induced immunopathological disturbances at the gut epithelial surface, which collectively contribute to OUD and perpetuate the vicious cycle of addiction and relapse. Graphical Abstract: [Figure not available: see fulltext.]

Original languageEnglish (US)
JournalJournal of Neuroimmune Pharmacology
StateAccepted/In press - 2022
Externally publishedYes


  • Enteric nervous system
  • Gut-brain axis
  • Microbiome
  • Opioids
  • OUD

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology


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