Opicapone for the treatment of Parkinson’s disease: a review

Matthew Feldman, Jason Margolesky

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Purpose: Levodopa formulations are the workhorses of the labor against motor symptoms management in Parkinson’s disease (PD). Progression of PD on levodopa inevitably leads to motor fluctuations. It is important to understand the safety and efficacy of opicapone, the most recent addition to the clinician’s armamentarium against these fluctuations. Materials and methods: We review the development of COMT inhibitors in the treatment of PD as well as the efficacy and safety data reported in the currently published literature of opicapone in PD. The “currently published literature” is defined as all published, PubMed indexed trials including the word “opicapone.” Finally, we compare opicapone to the competitor pharmaceuticals on the market to treat symptom fluctuations in PD and share our opinion of opicapone’s place in clinical practice. Results: From the reported results of phase 3 and 4 trials of opicapone in PD, it is a safe and efficacious option to combat motor fluctuations for our PD patients taking levodopa. A reduction of “off” time by up to 1 h per day can be expected, increasing “on” time with fewer dyskinesias. Opicapone is not generally hepatotoxic, and the most reported side-effects—dyskinesia, dry mouth, dizziness, diarrhea, and constipation—were seen in only 1.4% of the OPTIPARK (a large phase 4 clinical trial) study population. Conclusions: One should consider utilizing opicapone, perhaps in combination with other augmenting medications with different mechanisms of action, to help treat motor and non-motor fluctuations in PD.

Original languageEnglish (US)
JournalInternational Journal of Neuroscience
StateAccepted/In press - 2021


  • COMT inhibitors
  • drug review
  • motor fluctuations
  • Opicapone
  • Parkinson’s disease

ASJC Scopus subject areas

  • Neuroscience(all)


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