Ophthalmic applications of femtosecond lasers

Ron Kurtz, G. J R Spooner, Karin Sletten, Kim Yen, Samir Sayegh, Frieder Loesel, Christopher Horvath, Hsiao hua Liu, Victor Elner, Delia Cabrera DeBuc, Marie Helene Meunier, Zachary Sacks, Tibor Juhasz, Doug L. Miller, A. Roy Williams

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

We investigated three potential femtosecond laser ophthalmic procedures: intrastromal refractive surgery, transcleral photodisruptive glaucoma surgery and photodisruptive ultrasonic lens surgery. A highly reliable, all-solid-state system was used to investigate tissue effects and demonstrate clinical practicality. Compared with longer duration pulses, femtosecond laser-tissue interactions are characterized by smaller and more deterministic photodisruptive energy thresholds, smaller shock wave and cavitation bubble sizes. Scanning a 5 μ spot below the target tissue surface produced contiguous tissue effects. Various scanning patterns were used to evaluate the efficacy, safety, and stability of three intrastromal refractive procedures in animal eyes: corneal flap cutting, keratomileusis, and intrastromal vision correction (IVC). Superior dissection and surface quality results were obtained for the lamellar procedures. IVC in rabbits revealed consistent, stable pachymetric changes, without significant inflammation or corneal transparency degradation. Transcleral photodisruption was evaluated as a noninvasive method for creating partial thickness scleral channels to reduce elevated intraocular pressure associated with glaucoma. Photodisruption at the internal scleral surface was demonstrated by focusing through tissue in vitro without collateral damage. Femtosecond photodisruptions nucleated ultrasonically driven cavitation to demonstrate non-invasive destruction of in vitro lens tissue. We conclude that femtosecond lasers may enable practical novel ophthalmic procedures, offering advantages over current techniques.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages51-65
Number of pages15
Volume3616
StatePublished - 1999
Externally publishedYes
EventProceedings of the 1999 Commercial and Biomedical Applications of Ultrafast Lasers - San Jose, CA, USA
Duration: Jan 28 1999Jan 29 1999

Other

OtherProceedings of the 1999 Commercial and Biomedical Applications of Ultrafast Lasers
CitySan Jose, CA, USA
Period1/28/991/29/99

Fingerprint

Ultrashort pulses
Tissue
Vision aids
Surgery
surgery
glaucoma
lasers
Cavitation
cavitation flow
Lenses
Laser tissue interaction
Scanning
intraocular pressure
Dissection
lenses
dissection
Bubbles (in fluids)
scanning
Shock waves
Transparency

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Kurtz, R., Spooner, G. J. R., Sletten, K., Yen, K., Sayegh, S., Loesel, F., ... Williams, A. R. (1999). Ophthalmic applications of femtosecond lasers. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3616, pp. 51-65). Society of Photo-Optical Instrumentation Engineers.

Ophthalmic applications of femtosecond lasers. / Kurtz, Ron; Spooner, G. J R; Sletten, Karin; Yen, Kim; Sayegh, Samir; Loesel, Frieder; Horvath, Christopher; Liu, Hsiao hua; Elner, Victor; Cabrera DeBuc, Delia; Meunier, Marie Helene; Sacks, Zachary; Juhasz, Tibor; Miller, Doug L.; Williams, A. Roy.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3616 Society of Photo-Optical Instrumentation Engineers, 1999. p. 51-65.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kurtz, R, Spooner, GJR, Sletten, K, Yen, K, Sayegh, S, Loesel, F, Horvath, C, Liu, HH, Elner, V, Cabrera DeBuc, D, Meunier, MH, Sacks, Z, Juhasz, T, Miller, DL & Williams, AR 1999, Ophthalmic applications of femtosecond lasers. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3616, Society of Photo-Optical Instrumentation Engineers, pp. 51-65, Proceedings of the 1999 Commercial and Biomedical Applications of Ultrafast Lasers, San Jose, CA, USA, 1/28/99.
Kurtz R, Spooner GJR, Sletten K, Yen K, Sayegh S, Loesel F et al. Ophthalmic applications of femtosecond lasers. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3616. Society of Photo-Optical Instrumentation Engineers. 1999. p. 51-65
Kurtz, Ron ; Spooner, G. J R ; Sletten, Karin ; Yen, Kim ; Sayegh, Samir ; Loesel, Frieder ; Horvath, Christopher ; Liu, Hsiao hua ; Elner, Victor ; Cabrera DeBuc, Delia ; Meunier, Marie Helene ; Sacks, Zachary ; Juhasz, Tibor ; Miller, Doug L. ; Williams, A. Roy. / Ophthalmic applications of femtosecond lasers. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3616 Society of Photo-Optical Instrumentation Engineers, 1999. pp. 51-65
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AU - Loesel, Frieder

AU - Horvath, Christopher

AU - Liu, Hsiao hua

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AU - Cabrera DeBuc, Delia

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