Open lung biopsy in pediatric patients with respiratory failure after abdominal transplantation

Christopher Vendryes, Gwenn E. McLaughlin, Rita L. Romaguera, Juan Sola, Tomoaki Kato

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


To understand the utility of open lung biopsy (OLB) in the evaluation of respiratory failure in pediatric abdominal organ transplant we reviewed the records of nine children in this patient population who underwent an OLB. Eight of nine patients had undergone a previous non-diagnostic bronchoalveolar lavage. Biopsies were performed at the bedside in the pediatric intensive care unit and tissue was processed by the Department of Pathology with special stains for infectious agents. There were no significant complications of OLB. A specific treatable etiology was identified in four patients (respiratory syncytial virus, adenovirus, graft-vs.-host disease and post-transplant lymphoproliferative disease), leading to a change in therapy and survival in two. Overall survival was 44%. Given the low morbidity, OLB as performed in this study appears appropriate in this patient population.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
JournalPediatric Transplantation
Issue number2
StatePublished - Apr 1 2005


  • Adenovirus
  • Biopsy
  • Epstein-Barr virus infections
  • Graft-vs.-host disease
  • Interstitial
  • Intestinal transplantation
  • Liver transplantation
  • Lung diseases
  • Respiratory insufficiency
  • Respiratory syncytial virus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation


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