Onychomycosis

Does Cure Equate to Treatment Success?

Boni E. Elewski, Aditya K. Gupta, Ted Rosen, Bryan D. Caldwell, David M. Pariser, Leon H. Kircik, Neal Bhatia, Antonella Tosti

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

BACKGROUND: There is no general agreement as to what constitutes cure or treatment success in onychomycosis. Regulatory guidelines differ in the United States and Europe, and outcomes reported in clinical trials do not consistently report secondary endpoints.

METHODS: We reviewed definitions of onychomycosis cure to develop a less stringent and more practical approach to assess improvement and treatment success.

RESULTS: Complete cure (totally clear nail and mycologic cure) remains an important regulatory standard. Mycologic cure (negative fungal culture and negative potassium hydroxide) is the only consistently reported outcome in clinical trials, however the potential for discrepancies between microscopy and culture can be problematic. We propose a more practical approach to assessing improvement in infected nails that relies on both physician and patient input in a similar fashion to other skin diseases.

CONCLUSIONS: Treatment success should be based on both physician and patient assessment of improvement in the affected toenails and negative fungal culture.

J Drugs Dermatol. 2016;15(5):626-632.

Original languageEnglish (US)
Pages (from-to)626-632
Number of pages7
JournalJournal of drugs in dermatology : JDD
Volume15
Issue number5
StatePublished - May 1 2016

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Onychomycosis
Nails
Clinical Trials
Physicians
Skin Diseases
Microscopy
Therapeutics
Guidelines
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)
  • Dermatology

Cite this

Elewski, B. E., Gupta, A. K., Rosen, T., Caldwell, B. D., Pariser, D. M., Kircik, L. H., ... Tosti, A. (2016). Onychomycosis: Does Cure Equate to Treatment Success? Journal of drugs in dermatology : JDD, 15(5), 626-632.

Onychomycosis : Does Cure Equate to Treatment Success? / Elewski, Boni E.; Gupta, Aditya K.; Rosen, Ted; Caldwell, Bryan D.; Pariser, David M.; Kircik, Leon H.; Bhatia, Neal; Tosti, Antonella.

In: Journal of drugs in dermatology : JDD, Vol. 15, No. 5, 01.05.2016, p. 626-632.

Research output: Contribution to journalReview article

Elewski, BE, Gupta, AK, Rosen, T, Caldwell, BD, Pariser, DM, Kircik, LH, Bhatia, N & Tosti, A 2016, 'Onychomycosis: Does Cure Equate to Treatment Success?', Journal of drugs in dermatology : JDD, vol. 15, no. 5, pp. 626-632.
Elewski BE, Gupta AK, Rosen T, Caldwell BD, Pariser DM, Kircik LH et al. Onychomycosis: Does Cure Equate to Treatment Success? Journal of drugs in dermatology : JDD. 2016 May 1;15(5):626-632.
Elewski, Boni E. ; Gupta, Aditya K. ; Rosen, Ted ; Caldwell, Bryan D. ; Pariser, David M. ; Kircik, Leon H. ; Bhatia, Neal ; Tosti, Antonella. / Onychomycosis : Does Cure Equate to Treatment Success?. In: Journal of drugs in dermatology : JDD. 2016 ; Vol. 15, No. 5. pp. 626-632.
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AU - Bhatia, Neal

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