Onychomatricoma has channel-like structures on in vivo reflectance confocal microscopy

M. I. Sanchez, S. Hu, M. Miteva, A. Tosti

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background: Onychomatricoma is a benign fibroepithelial nail matrix tumor that infiltrates the nail plate leading to multiple tunneled cavities lined with matrix epithelium and filled with serum. Diagnostic features of onychomatricoma on reflectance confocal microscopy (RCM) have not been previously described. Objective: We sought to demonstrate the feasibility of using RCM to diagnose onychomatricoma. Methods: Reflectance confocal microscopy was used to evaluate four patients with onychomatricoma before tumor excision. We evaluated the affected nail and one unaffected nail of each patient with VivaScope 1500 (Lucid Inc., Rochester, NY, USA). Results: Reflectance confocal microscopy evaluation of onychomatricomas revealed longitudinal dark areas and bright/grey lines, forming channel like structures. The channels were outlined by bright circular lines with grey dot centers. These RCM features correlated with the pathology of the onychomatricomas within the nail plate. Limitations: Proximal portion of onychomatricoma was not reach by RCM. Conclusions: Reflectance confocal microscopy can assist in rapid and noninvasive diagnosis of onychomatricoma showing characteristic channel like structures within nail plates.

Original languageEnglish (US)
Pages (from-to)1560-1562
Number of pages3
JournalJournal of the European Academy of Dermatology and Venereology
Issue number11
StatePublished - Nov 1 2014

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases


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