Abstract
Neurotensin (NT), an endogenous tridecapeptide, when given intracisternally (i.c.) elicits significant hypothermia in a variety of mammals. The present study was designed to test the ability of centrally administered NT to induce a hypothermic effect in rats at different ages. Intracisternally administered NT (10 and 30 microgram) produced a marked dose-dependent hypothermia in rats aged 5, 10, 20, 30 and 60 days. This study confirms and extends the previously reported hypothermic effect of centrally administered NT in the rat and documents the responsiveness of young animals to the peptide.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 497-501 |
| Number of pages | 5 |
| Journal | Developmental Brain Research |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1982 |
| Externally published | Yes |
Keywords
- hypothermic response
- neurotensin
- ontogenesis
ASJC Scopus subject areas
- Developmental Neuroscience
- Developmental Biology
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Hernandez, D. E., Nemeroff, C. B., & Prange, A. J. (1982). Ontogeny of the hypothermic response to centrally administered neurotensin in rats. Developmental Brain Research, 3(3), 497-501. https://doi.org/10.1016/0165-3806(82)90016-5