Ontogeny of the hypothermic response to centrally administered neurotensin in rats

Daniel E. Hernandez; Charles B. Nemeroff; Arthur J. Prange

doi:10.1016/0165-3806(82)90016-5

Ontogeny of the hypothermic response to centrally administered neurotensin in rats

Daniel E. Hernandez, Charles B. Nemeroff, Arthur J. Prange

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Neurotensin (NT), an endogenous tridecapeptide, when given intracisternally (i.c.) elicits significant hypothermia in a variety of mammals. The present study was designed to test the ability of centrally administered NT to induce a hypothermic effect in rats at different ages. Intracisternally administered NT (10 and 30 microgram) produced a marked dose-dependent hypothermia in rats aged 5, 10, 20, 30 and 60 days. This study confirms and extends the previously reported hypothermic effect of centrally administered NT in the rat and documents the responsiveness of young animals to the peptide.

Original language	English (US)
Pages (from-to)	497-501
Number of pages	5
Journal	Developmental Brain Research
Volume	3
Issue number	3
DOIs	https://doi.org/10.1016/0165-3806(82)90016-5
State	Published - Mar 1982
Externally published	Yes

Keywords

hypothermic response
neurotensin
ontogenesis

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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abstract = "Neurotensin (NT), an endogenous tridecapeptide, when given intracisternally (i.c.) elicits significant hypothermia in a variety of mammals. The present study was designed to test the ability of centrally administered NT to induce a hypothermic effect in rats at different ages. Intracisternally administered NT (10 and 30 microgram) produced a marked dose-dependent hypothermia in rats aged 5, 10, 20, 30 and 60 days. This study confirms and extends the previously reported hypothermic effect of centrally administered NT in the rat and documents the responsiveness of young animals to the peptide.",

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AU - Nemeroff, Charles B.

AU - Prange, Arthur J.

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AB - Neurotensin (NT), an endogenous tridecapeptide, when given intracisternally (i.c.) elicits significant hypothermia in a variety of mammals. The present study was designed to test the ability of centrally administered NT to induce a hypothermic effect in rats at different ages. Intracisternally administered NT (10 and 30 microgram) produced a marked dose-dependent hypothermia in rats aged 5, 10, 20, 30 and 60 days. This study confirms and extends the previously reported hypothermic effect of centrally administered NT in the rat and documents the responsiveness of young animals to the peptide.

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