Ontogeny of peptidylglycine alpha-amidating monooxygenase activity in rapidly mineralizing bone from neonatal mouse

Roger S. Birnbaum, Guy A. Howard, Bernard A. Roos

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Peptidylglycine alpha-amidating monooxygenase is hormonally, developmentally, and nutritionally regulated. In several tissues concomitant changes in enzyme activity and the level of expression of a known amidated peptide have been demonstrated. We report that neonatal mouse calvarium, a rapidly mineralization bone, has detectable amidation enzyme activity. The level of activity varied 3-10-fold during the first 9 d of life. Production of one or more amidated peptides by bone may be coordinately regulated.

Original languageEnglish (US)
Pages (from-to)3134-3136
Number of pages3
JournalEndocrinology
Volume124
Issue number6
DOIs
StatePublished - Jun 1989

ASJC Scopus subject areas

  • Endocrinology

Fingerprint Dive into the research topics of 'Ontogeny of peptidylglycine alpha-amidating monooxygenase activity in rapidly mineralizing bone from neonatal mouse'. Together they form a unique fingerprint.

  • Cite this