TY - JOUR
T1 - Ontogeny of lymphocyte subpopulations in human fetal liver
AU - Gupta, S.
AU - Pahwa, R.
AU - O'Reilly, R.
AU - Good, R. A.
AU - Siegal, F. P.
PY - 1976
Y1 - 1976
N2 - Lymphocytes were isolated from 5 fetal livers (13-17 wk) and examined for different surface markers. Immunoglobulin M was found on 0.5-4.0% of lymphocytes. No membrane bound surface IgD, IgA, or IgG was detected. Mouse erythrocyte rosette forming lymphocytes ranged from 0.5 to 6.0%. Thymus processed (T) lymphocytes, which were defined as those forming spontaneous rosettes with sheep erythrocytes, as well as lymphocytes with IgG Fc receptors, were present in a small proportion. No complement receptor bearing lymphocytes were found in the 2 cell populations of fetal liver studied. It is evident that during the ontogeny of bone marrow derived (B) lymphocytes IgM is the first surface immunoglobulin to appear. Receptors for the binding of mouse erythrocytes are present at the same time as surface IgM. The slight excess of mouse erythrocyte rosette forming cells over cells having surface immunoglobulin M could mean that IgM appears later than do the receptors for the binding of mouse erythrocytes.
AB - Lymphocytes were isolated from 5 fetal livers (13-17 wk) and examined for different surface markers. Immunoglobulin M was found on 0.5-4.0% of lymphocytes. No membrane bound surface IgD, IgA, or IgG was detected. Mouse erythrocyte rosette forming lymphocytes ranged from 0.5 to 6.0%. Thymus processed (T) lymphocytes, which were defined as those forming spontaneous rosettes with sheep erythrocytes, as well as lymphocytes with IgG Fc receptors, were present in a small proportion. No complement receptor bearing lymphocytes were found in the 2 cell populations of fetal liver studied. It is evident that during the ontogeny of bone marrow derived (B) lymphocytes IgM is the first surface immunoglobulin to appear. Receptors for the binding of mouse erythrocytes are present at the same time as surface IgM. The slight excess of mouse erythrocyte rosette forming cells over cells having surface immunoglobulin M could mean that IgM appears later than do the receptors for the binding of mouse erythrocytes.
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U2 - 10.1073/pnas.73.3.919
DO - 10.1073/pnas.73.3.919
M3 - Article
C2 - 1062806
AN - SCOPUS:0017239944
VL - 73
SP - 919
EP - 922
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 3
ER -