Ontogeny of hemoglobins: Evidence for hemoglobin M

Robert W. Keane; Ursula K. Abbott; J. Lynne Brown; Vernon M. Ingram

doi:10.1016/0012-1606(74)90003-7

Ontogeny of hemoglobins: Evidence for hemoglobin M

Robert W. Keane, Ursula K. Abbott, J. Lynne Brown, Vernon M. Ingram

Research output: Contribution to journal › Article

9 Scopus citations

Abstract

A new autosomal codominant hemoglobin mutation alters hemoglobin M of the primitive red cell line and hemoglobin D found in definitive cells. That Hb M and Hb D are altered by the same gene mutation supports the idea that Hb M shares a polypeptide chain with Hb D. It is concluded that in the switch from primitive hemoglobins to those of the definitive type, there are at least two α chains conserved; α^A of Hb E in Hb A and α^D of Hb M in Hb D.

Original language	English (US)
Pages (from-to)	229-236
Number of pages	8
Journal	Developmental Biology
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/0012-1606(74)90003-7
State	Published - Jun 1974
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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Keane, R. W., Abbott, U. K., Brown, J. L., & Ingram, V. M. (1974). Ontogeny of hemoglobins: Evidence for hemoglobin M. Developmental Biology, 38(2), 229-236. https://doi.org/10.1016/0012-1606(74)90003-7

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abstract = "A new autosomal codominant hemoglobin mutation alters hemoglobin M of the primitive red cell line and hemoglobin D found in definitive cells. That Hb M and Hb D are altered by the same gene mutation supports the idea that Hb M shares a polypeptide chain with Hb D. It is concluded that in the switch from primitive hemoglobins to those of the definitive type, there are at least two α chains conserved; αA of Hb E in Hb A and αD of Hb M in Hb D.",

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AU - Brown, J. Lynne

AU - Ingram, Vernon M.

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AB - A new autosomal codominant hemoglobin mutation alters hemoglobin M of the primitive red cell line and hemoglobin D found in definitive cells. That Hb M and Hb D are altered by the same gene mutation supports the idea that Hb M shares a polypeptide chain with Hb D. It is concluded that in the switch from primitive hemoglobins to those of the definitive type, there are at least two α chains conserved; αA of Hb E in Hb A and αD of Hb M in Hb D.

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