Ontogeny of hemoglobins: Evidence for hemoglobin M

Robert W. Keane, Ursula K. Abbott, J. Lynne Brown, Vernon M. Ingram

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


A new autosomal codominant hemoglobin mutation alters hemoglobin M of the primitive red cell line and hemoglobin D found in definitive cells. That Hb M and Hb D are altered by the same gene mutation supports the idea that Hb M shares a polypeptide chain with Hb D. It is concluded that in the switch from primitive hemoglobins to those of the definitive type, there are at least two α chains conserved; αA of Hb E in Hb A and αD of Hb M in Hb D.

Original languageEnglish (US)
Pages (from-to)229-236
Number of pages8
JournalDevelopmental Biology
Issue number2
StatePublished - Jun 1974
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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