Ontogeny of hemoglobins: Evidence for hemoglobin M

Robert Keane, Ursula K. Abbott, J. Lynne Brown, Vernon M. Ingram

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A new autosomal codominant hemoglobin mutation alters hemoglobin M of the primitive red cell line and hemoglobin D found in definitive cells. That Hb M and Hb D are altered by the same gene mutation supports the idea that Hb M shares a polypeptide chain with Hb D. It is concluded that in the switch from primitive hemoglobins to those of the definitive type, there are at least two α chains conserved; αA of Hb E in Hb A and αD of Hb M in Hb D.

Original languageEnglish
Pages (from-to)229-236
Number of pages8
JournalDevelopmental Biology
Volume38
Issue number2
DOIs
StatePublished - Jan 1 1974
Externally publishedYes

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Hemoglobin M
Hemoglobins
Mutation
hemoglobin D
Cell Line
Peptides
Genes

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Ontogeny of hemoglobins : Evidence for hemoglobin M. / Keane, Robert; Abbott, Ursula K.; Brown, J. Lynne; Ingram, Vernon M.

In: Developmental Biology, Vol. 38, No. 2, 01.01.1974, p. 229-236.

Research output: Contribution to journalArticle

Keane, Robert ; Abbott, Ursula K. ; Brown, J. Lynne ; Ingram, Vernon M. / Ontogeny of hemoglobins : Evidence for hemoglobin M. In: Developmental Biology. 1974 ; Vol. 38, No. 2. pp. 229-236.
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