Abstract
A new autosomal codominant hemoglobin mutation alters hemoglobin M of the primitive red cell line and hemoglobin D found in definitive cells. That Hb M and Hb D are altered by the same gene mutation supports the idea that Hb M shares a polypeptide chain with Hb D. It is concluded that in the switch from primitive hemoglobins to those of the definitive type, there are at least two α chains conserved; αA of Hb E in Hb A and αD of Hb M in Hb D.
| Original language | English |
|---|---|
| Pages (from-to) | 229-236 |
| Number of pages | 8 |
| Journal | Developmental Biology |
| Volume | 38 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1974 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Developmental Biology
Cite this
Ontogeny of hemoglobins : Evidence for hemoglobin M. / Keane, Robert; Abbott, Ursula K.; Brown, J. Lynne; Ingram, Vernon M.
In: Developmental Biology, Vol. 38, No. 2, 01.01.1974, p. 229-236.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ontogeny of hemoglobins
T2 - Evidence for hemoglobin M
AU - Keane, Robert
AU - Abbott, Ursula K.
AU - Brown, J. Lynne
AU - Ingram, Vernon M.
PY - 1974/1/1
Y1 - 1974/1/1
N2 - A new autosomal codominant hemoglobin mutation alters hemoglobin M of the primitive red cell line and hemoglobin D found in definitive cells. That Hb M and Hb D are altered by the same gene mutation supports the idea that Hb M shares a polypeptide chain with Hb D. It is concluded that in the switch from primitive hemoglobins to those of the definitive type, there are at least two α chains conserved; αA of Hb E in Hb A and αD of Hb M in Hb D.
AB - A new autosomal codominant hemoglobin mutation alters hemoglobin M of the primitive red cell line and hemoglobin D found in definitive cells. That Hb M and Hb D are altered by the same gene mutation supports the idea that Hb M shares a polypeptide chain with Hb D. It is concluded that in the switch from primitive hemoglobins to those of the definitive type, there are at least two α chains conserved; αA of Hb E in Hb A and αD of Hb M in Hb D.
UR - http://www.scopus.com/inward/record.url?scp=0016161749&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016161749&partnerID=8YFLogxK
U2 - 10.1016/0012-1606(74)90003-7
DO - 10.1016/0012-1606(74)90003-7
M3 - Article
C2 - 4831107
AN - SCOPUS:0016161749
VL - 38
SP - 229
EP - 236
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
IS - 2
ER -