Abstract
A new autosomal codominant hemoglobin mutation alters hemoglobin M of the primitive red cell line and hemoglobin D found in definitive cells. That Hb M and Hb D are altered by the same gene mutation supports the idea that Hb M shares a polypeptide chain with Hb D. It is concluded that in the switch from primitive hemoglobins to those of the definitive type, there are at least two α chains conserved; αA of Hb E in Hb A and αD of Hb M in Hb D.
Original language | English (US) |
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Pages (from-to) | 229-236 |
Number of pages | 8 |
Journal | Developmental Biology |
Volume | 38 |
Issue number | 2 |
DOIs | |
State | Published - Jun 1974 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology
- Cell Biology