Ontogeny of Brain Neurotensin in the Rat: A Radioimmunoassay Study

Garth Bissette, Charles Richardson, John S. Kizer, Charles B. Nemeroff

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Concentrations of neurotensin-like immunoreactivity in several discrete brain areas were measured by radioimmunoassay in rats of different ages (2, 5, 10, 20, 30, and 60 days). Neurotensin-like immunoreactivity increased steadily from 2 to 30 days of age in the hypothalamus and then plateaued, while the preoptic area and amygdala concentrations peaked at 30 days of age. Brainstem neurotensin-like immunoreactivity concentrations increased from 2 to 10 days of age and decreased from 20 to 60 days of age. Several other regions showed no significant age-associated changes in neurotensin-like immunoreactivity.

Original languageEnglish (US)
Pages (from-to)283-287
Number of pages5
JournalJournal of neurochemistry
Volume43
Issue number1
DOIs
StatePublished - Jul 1984

Keywords

  • Neurotensin
  • Ontogeny
  • Peptides
  • Radioimmunoassay

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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