Abstract
Based on recent findings of this laboratory, the hypothesis was tested that a single stressful encounter might have a persistent antidiazepam influence. Our results indicate that one exposure to a brief stressful event up to at least one month earlier prevented completely the effect of diazepam on pentylenetetrazole-induced changes in dopamine in the rat frontal cortex, elevations of plasma corticosterone levels and seizures.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 380-385 |
| Number of pages | 6 |
| Journal | Brain Research |
| Volume | 445 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 5 1988 |
| Externally published | Yes |
Keywords
- Benzodiazepine
- Corticosteronne
- Diazepam
- Pentylenetetrazole
- Post-traumatic stress disorder
- Sensitization
- Stress
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
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Antelman, S. M., Knopf, S., Kocan, D., Edwards, D. J., Ritchie, J. C., & Nemeroff, C. B. (1988). One stressful event blocks multiple actions of diazepam for up to at least a month. Brain Research, 445(2), 380-385. https://doi.org/10.1016/0006-8993(88)91204-8