One stressful event blocks multiple actions of diazepam for up to at least a month

Seymour M. Antelman, Steven Knopf, Donna Kocan, David J. Edwards, James C. Ritchie, Charles B. Nemeroff

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Based on recent findings of this laboratory, the hypothesis was tested that a single stressful encounter might have a persistent antidiazepam influence. Our results indicate that one exposure to a brief stressful event up to at least one month earlier prevented completely the effect of diazepam on pentylenetetrazole-induced changes in dopamine in the rat frontal cortex, elevations of plasma corticosterone levels and seizures.

Original languageEnglish (US)
Pages (from-to)380-385
Number of pages6
JournalBrain Research
Volume445
Issue number2
DOIs
StatePublished - Apr 5 1988
Externally publishedYes

Keywords

  • Benzodiazepine
  • Corticosteronne
  • Diazepam
  • Pentylenetetrazole
  • Post-traumatic stress disorder
  • Sensitization
  • Stress

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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