Abstract
Based on recent findings of this laboratory, the hypothesis was tested that a single stressful encounter might have a persistent antidiazepam influence. Our results indicate that one exposure to a brief stressful event up to at least one month earlier prevented completely the effect of diazepam on pentylenetetrazole-induced changes in dopamine in the rat frontal cortex, elevations of plasma corticosterone levels and seizures.
Original language | English (US) |
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Pages (from-to) | 380-385 |
Number of pages | 6 |
Journal | Brain research |
Volume | 445 |
Issue number | 2 |
DOIs | |
State | Published - Apr 5 1988 |
Externally published | Yes |
Keywords
- Benzodiazepine
- Corticosteronne
- Diazepam
- Pentylenetetrazole
- Post-traumatic stress disorder
- Sensitization
- Stress
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)