One stressful event blocks multiple actions of diazepam for up to at least a month

Seymour M. Antelman; Steven Knopf; Donna Kocan; David J. Edwards; James C. Ritchie; Charles B. Nemeroff

doi:10.1016/0006-8993(88)91204-8

One stressful event blocks multiple actions of diazepam for up to at least a month

Seymour M. Antelman, Steven Knopf, Donna Kocan, David J. Edwards, James C. Ritchie, Charles B. Nemeroff

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Based on recent findings of this laboratory, the hypothesis was tested that a single stressful encounter might have a persistent antidiazepam influence. Our results indicate that one exposure to a brief stressful event up to at least one month earlier prevented completely the effect of diazepam on pentylenetetrazole-induced changes in dopamine in the rat frontal cortex, elevations of plasma corticosterone levels and seizures.

Original language	English (US)
Pages (from-to)	380-385
Number of pages	6
Journal	Brain research
Volume	445
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(88)91204-8
State	Published - Apr 5 1988
Externally published	Yes

Keywords

Benzodiazepine
Corticosteronne
Diazepam
Pentylenetetrazole
Post-traumatic stress disorder
Sensitization
Stress

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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10.1016/0006-8993(88)91204-8

Cite this

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title = "One stressful event blocks multiple actions of diazepam for up to at least a month",

abstract = "Based on recent findings of this laboratory, the hypothesis was tested that a single stressful encounter might have a persistent antidiazepam influence. Our results indicate that one exposure to a brief stressful event up to at least one month earlier prevented completely the effect of diazepam on pentylenetetrazole-induced changes in dopamine in the rat frontal cortex, elevations of plasma corticosterone levels and seizures.",

keywords = "Benzodiazepine, Corticosteronne, Diazepam, Pentylenetetrazole, Post-traumatic stress disorder, Sensitization, Stress",

author = "Antelman, {Seymour M.} and Steven Knopf and Donna Kocan and Edwards, {David J.} and Ritchie, {James C.} and Nemeroff, {Charles B.}",

note = "Funding Information: We thank Karen Fletcher for typing the manuscript. Supported by MH24114, MH00238, the Scottish Rite Schizophrenia Research Program, NMJ (to S.M.A.), MH42088 and MH39415 (to C.B.N.) and Clinical Research Center Grant MH30915.",

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T1 - One stressful event blocks multiple actions of diazepam for up to at least a month

AU - Antelman, Seymour M.

AU - Knopf, Steven

AU - Kocan, Donna

AU - Edwards, David J.

AU - Ritchie, James C.

AU - Nemeroff, Charles B.

N1 - Funding Information: We thank Karen Fletcher for typing the manuscript. Supported by MH24114, MH00238, the Scottish Rite Schizophrenia Research Program, NMJ (to S.M.A.), MH42088 and MH39415 (to C.B.N.) and Clinical Research Center Grant MH30915.

PY - 1988/4/5

Y1 - 1988/4/5

N2 - Based on recent findings of this laboratory, the hypothesis was tested that a single stressful encounter might have a persistent antidiazepam influence. Our results indicate that one exposure to a brief stressful event up to at least one month earlier prevented completely the effect of diazepam on pentylenetetrazole-induced changes in dopamine in the rat frontal cortex, elevations of plasma corticosterone levels and seizures.

AB - Based on recent findings of this laboratory, the hypothesis was tested that a single stressful encounter might have a persistent antidiazepam influence. Our results indicate that one exposure to a brief stressful event up to at least one month earlier prevented completely the effect of diazepam on pentylenetetrazole-induced changes in dopamine in the rat frontal cortex, elevations of plasma corticosterone levels and seizures.

KW - Benzodiazepine

KW - Corticosteronne

KW - Diazepam

KW - Pentylenetetrazole

KW - Post-traumatic stress disorder

KW - Sensitization

KW - Stress

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One stressful event blocks multiple actions of diazepam for up to at least a month

Abstract

Keywords

ASJC Scopus subject areas

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