One stressful event blocks multiple actions of diazepam for up to at least a month

Seymour M. Antelman, Steven Knopf, Donna Kocan, David J. Edwards, James C. Ritchie, Charles Nemeroff

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Based on recent findings of this laboratory, the hypothesis was tested that a single stressful encounter might have a persistent antidiazepam influence. Our results indicate that one exposure to a brief stressful event up to at least one month earlier prevented completely the effect of diazepam on pentylenetetrazole-induced changes in dopamine in the rat frontal cortex, elevations of plasma corticosterone levels and seizures.

Original languageEnglish
Pages (from-to)380-385
Number of pages6
JournalBrain Research
Volume445
Issue number2
DOIs
StatePublished - Apr 5 1988
Externally publishedYes

Fingerprint

Pentylenetetrazole
Frontal Lobe
Diazepam
Corticosterone
Dopamine
Seizures

Keywords

  • Benzodiazepine
  • Corticosteronne
  • Diazepam
  • Pentylenetetrazole
  • Post-traumatic stress disorder
  • Sensitization
  • Stress

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

One stressful event blocks multiple actions of diazepam for up to at least a month. / Antelman, Seymour M.; Knopf, Steven; Kocan, Donna; Edwards, David J.; Ritchie, James C.; Nemeroff, Charles.

In: Brain Research, Vol. 445, No. 2, 05.04.1988, p. 380-385.

Research output: Contribution to journalArticle

Antelman, Seymour M. ; Knopf, Steven ; Kocan, Donna ; Edwards, David J. ; Ritchie, James C. ; Nemeroff, Charles. / One stressful event blocks multiple actions of diazepam for up to at least a month. In: Brain Research. 1988 ; Vol. 445, No. 2. pp. 380-385.
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