One-step fabrication of size-controllable nicotine containing core-shell structures

Jeongmin Hong, Rakesh Guduru, Sakhrat Khizroev, Long You

Research output: Contribution to journalArticlepeer-review


We report a one-step synthesis of nicotine-containing nanoparticles by using a size-controllable nanofiltration technique. Nanostructures with polydimethylsiloxane (PDMS) were prepared as a biocompatible well-type polymeric carrier containing a hydrophobic and highly viscous nicotine drug through a novel spontaneous emulsification solvent diffusion method. This approach could be used for efficient dispersion of nicotine in biological systems. Our present results, together with size controllability, pave a way to new types of functional material structures for novel transdermal pharmaceuticals that contain nicotine/cotinine in nanosized structures.

Original languageEnglish (US)
Pages (from-to)1305-1313
Number of pages9
JournalNanoscale Advances
Issue number4
StatePublished - 2019

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Atomic and Molecular Physics, and Optics
  • Materials Science(all)
  • Engineering(all)


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