One-carbon metabolism and schizophrenia: current challenges and future directions

M. O. Krebs, Alfredo Bellon, Gaell Mainguy, T. M. Jay, Helge Frieling

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Schizophrenia is a heterogeneous disease generally considered to result from a combination of heritable and environmental factors. Although its pathophysiology has not been fully determined, biological studies support the involvement of several possible components including altered DNA methylation, abnormal glutamatergic transmission, altered mitochondrial function, folate deficiency and high maternal homocysteine levels. Although these factors have been explored separately, they all involve one-carbon (C1) metabolism. Furthermore, C1 metabolism is well positioned to integrate gene-environment interactions by influencing epigenetic regulation. Here, we discuss the potential roles of C1 metabolism in the pathophysiology of schizophrenia. Understanding the contribution of these mechanisms could yield new therapeutic approaches aiming to counteract disease onset or progression.

Original languageEnglish (US)
Pages (from-to)562-570
Number of pages9
JournalTrends in Molecular Medicine
Volume15
Issue number12
DOIs
StatePublished - Dec 1 2009

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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