Oncomine meta-analysis of breast cancer microarray data identifies upregulation of NRF-1 expression in human breast carcinoma

B. Kunkle, Q. Felty, F. Trevino, D. Roy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

We have conducted a study where Oncomine microarray data was meta-analyzed to evaluate NRF-1 gene expression in human breast tumors. Our initial analyses indicated that NRF-1 gene is differentially expressed in breast cancer patients based on their estrogen receptor (ER) status. Therefore, in our first meta-analyses 18 studies were grouped separately for ER+ and ER- patients. It was observed that NRF-1 gene expression is up-regulated in ER + patients compared to ER- patients. Further, two separate meta-analyses on ER+ and ER- patients were conducted to associate NRF-1 gene expression levels for prognosis and for histological grades of breast tumors. In a combined 15 microarray studies, ER- patients with down regulated NRF-1 expression either died or had a relapse of cancer after the treatment. ER+ patients with increased levels of NRF-1 expression however, survived or had no relapse after treatment. Interestingly, in our third set of meta-analyses conducted on 15 studies, it was observed that NRF-1 gene expression also increased significantly with the progression of tumor grades from 1 to 3. Findings of this study have a major implication for the role of NRF-1 in the breast cancer, suggesting that NRF-1 possibly participates in the growth of breast cancer by altering its activity.

Original languageEnglish (US)
Title of host publication18th World IMACS Congress and MODSIM 2009 - International Congress on Modelling and Simulation
Subtitle of host publicationInterfacing Modelling and Simulation with Mathematical and Computational Sciences, Proceedings
EditorsR.S. Anderssen, R.D. Braddock, L.T.H. Newham
PublisherModelling and Simulation Society of Australia and New Zealand Inc. (MSSANZ)
Pages715-719
Number of pages5
ISBN (Electronic)9780975840078
StatePublished - Jan 1 2009
Externally publishedYes
Event18th World IMACS Congress and International Congress on Modelling and Simulation: Interfacing Modelling and Simulation with Mathematical and Computational Sciences, MODSIM 2009 - Cairns, Australia
Duration: Jul 13 2009Jul 17 2009

Publication series

Name18th World IMACS Congress and MODSIM 2009 - International Congress on Modelling and Simulation: Interfacing Modelling and Simulation with Mathematical and Computational Sciences, Proceedings

Conference

Conference18th World IMACS Congress and International Congress on Modelling and Simulation: Interfacing Modelling and Simulation with Mathematical and Computational Sciences, MODSIM 2009
Country/TerritoryAustralia
CityCairns
Period7/13/097/17/09

Keywords

  • Breast cancer
  • Estrogen receptor
  • NRF1
  • Oncomine

ASJC Scopus subject areas

  • Modeling and Simulation

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