Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells

Shanchun Guo, Mingli Liu, Guangdi Wang, Marta Torroella-Kouri, Ruben R. Gonzalez-Perez

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Significant correlations between obesity and incidence of various cancers have been reported. Obesity, considered a mild inflammatory process, is characterized by a high level of secretion of several cytokines from adipose tissue. These molecules have disparate effects, which could be relevant to cancer development. Among the inflammatory molecules, leptin, mainly produced by adipose tissue and overexpressed with its receptor (Ob-R) in cancer cells is the most studied adipokine. Mutations of leptin or Ob-R genes associated with obesity or cancer are rarely found. However, leptin is an anti-apoptotic molecule in many cell types, and its central roles in obesity-related cancers are based on its pro-angiogenic, pro-inflammatory and mitogenic actions. Notably, these leptin actions are commonly reinforced through entangled crosstalk with multiple oncogenes, cytokines and growth factors. Leptin-induced signals comprise several pathways commonly triggered by many cytokines (i.e., canonical: JAK2/STAT; MAPK/ERK1/2 and PI-3K/AKT1 and, non-canonical signaling pathways: PKC, JNK and p38 MAP kinase). Each of these leptin-induced signals is essential to its biological effects on food intake, energy balance, adiposity, immune and endocrine systems, as well as oncogenesis. This review is mainly focused on the current knowledge of the oncogenic role of leptin in breast cancer. Additionally, leptin pro-angiogenic molecular mechanisms and its potential role in breast cancer stem cells will be reviewed. Strict biunivocal binding-affinity and activation of leptin/Ob-R complex makes it a unique molecular target for prevention and treatment of breast cancer, particularly in obesity contexts.

Original languageEnglish
Pages (from-to)207-222
Number of pages16
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1825
Issue number2
DOIs
StatePublished - Apr 1 2012

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Neoplastic Stem Cells
Leptin
Breast Neoplasms
Obesity
Therapeutics
Neoplasms
Cytokines
Adipose Tissue
vpr Genes
Endocrine System
Adipokines
MAP Kinase Signaling System
Adiposity
p38 Mitogen-Activated Protein Kinases
Phosphatidylinositol 3-Kinases
Oncogenes
Immune System
Intercellular Signaling Peptides and Proteins
Carcinogenesis
Eating

Keywords

  • Breast cancer
  • Breast cancer stem cells
  • Leptin
  • Leptin antagonist
  • Leptin signaling
  • Tumor angiogenesis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

Cite this

Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells. / Guo, Shanchun; Liu, Mingli; Wang, Guangdi; Torroella-Kouri, Marta; Gonzalez-Perez, Ruben R.

In: Biochimica et Biophysica Acta - Reviews on Cancer, Vol. 1825, No. 2, 01.04.2012, p. 207-222.

Research output: Contribution to journalArticle

Guo, Shanchun ; Liu, Mingli ; Wang, Guangdi ; Torroella-Kouri, Marta ; Gonzalez-Perez, Ruben R. / Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells. In: Biochimica et Biophysica Acta - Reviews on Cancer. 2012 ; Vol. 1825, No. 2. pp. 207-222.
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