On the tryptophan residue in porcine LH and FSH-releasing hormone

Yoshihiko Baba, Akira Arimura, Andrew V Schally

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effect of 2-hydroxy-5-nitrobenzyl bromide on the biological activity of a preparation of pure porcine LH and FSH-releasing hormone (LH-RH/FSH-RH) was reinvestigated. Since this treatment as well as performic acid and incubation with anhydrous trifluoroacetic acid, caused a complete inactivation of LH-RH/FSH-RH, tryptophan residue is thought to be essential for the biological activity of this polypeptide.

Original languageEnglish
Pages (from-to)483-487
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume45
Issue number2
DOIs
StatePublished - Oct 15 1971
Externally publishedYes

Fingerprint

Gonadotropin-Releasing Hormone
Tryptophan
Swine
Bioactivity
2-Hydroxy-5-nitrobenzyl Bromide
Trifluoroacetic Acid
Peptides
peroxyformic acid

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

On the tryptophan residue in porcine LH and FSH-releasing hormone. / Baba, Yoshihiko; Arimura, Akira; Schally, Andrew V.

In: Biochemical and Biophysical Research Communications, Vol. 45, No. 2, 15.10.1971, p. 483-487.

Research output: Contribution to journalArticle

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