On the tryptophan residue in porcine LH and FSH-releasing hormone

Yoshihiko Baba, Akira Arimura, Andrew V. Schally

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The effect of 2-hydroxy-5-nitrobenzyl bromide on the biological activity of a preparation of pure porcine LH and FSH-releasing hormone (LH-RH/FSH-RH) was reinvestigated. Since this treatment as well as performic acid and incubation with anhydrous trifluoroacetic acid, caused a complete inactivation of LH-RH/FSH-RH, tryptophan residue is thought to be essential for the biological activity of this polypeptide.

Original languageEnglish (US)
Pages (from-to)483-487
Number of pages5
JournalBiochemical and biophysical research communications
Volume45
Issue number2
DOIs
StatePublished - Oct 15 1971
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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