On the tryptophan residue in porcine LH and FSH-releasing hormone

Yoshihiko Baba; Akira Arimura; Andrew V. Schally

doi:10.1016/0006-291X(71)90844-8

On the tryptophan residue in porcine LH and FSH-releasing hormone

Yoshihiko Baba, Akira Arimura, Andrew V. Schally

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The effect of 2-hydroxy-5-nitrobenzyl bromide on the biological activity of a preparation of pure porcine LH and FSH-releasing hormone (LH-RH/FSH-RH) was reinvestigated. Since this treatment as well as performic acid and incubation with anhydrous trifluoroacetic acid, caused a complete inactivation of LH-RH/FSH-RH, tryptophan residue is thought to be essential for the biological activity of this polypeptide.

Original language	English (US)
Pages (from-to)	483-487
Number of pages	5
Journal	Biochemical and biophysical research communications
Volume	45
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(71)90844-8
State	Published - Oct 15 1971
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(71)90844-8

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title = "On the tryptophan residue in porcine LH and FSH-releasing hormone",

abstract = "The effect of 2-hydroxy-5-nitrobenzyl bromide on the biological activity of a preparation of pure porcine LH and FSH-releasing hormone (LH-RH/FSH-RH) was reinvestigated. Since this treatment as well as performic acid and incubation with anhydrous trifluoroacetic acid, caused a complete inactivation of LH-RH/FSH-RH, tryptophan residue is thought to be essential for the biological activity of this polypeptide.",

author = "Yoshihiko Baba and Akira Arimura and Schally, {Andrew V.}",

note = "Funding Information: Supported by grants from VA, New York, New York to AVS.",

year = "1971",

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doi = "10.1016/0006-291X(71)90844-8",

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T1 - On the tryptophan residue in porcine LH and FSH-releasing hormone

AU - Baba, Yoshihiko

AU - Arimura, Akira

AU - Schally, Andrew V.

N1 - Funding Information: Supported by grants from VA, New York, New York to AVS.

PY - 1971/10/15

Y1 - 1971/10/15

N2 - The effect of 2-hydroxy-5-nitrobenzyl bromide on the biological activity of a preparation of pure porcine LH and FSH-releasing hormone (LH-RH/FSH-RH) was reinvestigated. Since this treatment as well as performic acid and incubation with anhydrous trifluoroacetic acid, caused a complete inactivation of LH-RH/FSH-RH, tryptophan residue is thought to be essential for the biological activity of this polypeptide.

AB - The effect of 2-hydroxy-5-nitrobenzyl bromide on the biological activity of a preparation of pure porcine LH and FSH-releasing hormone (LH-RH/FSH-RH) was reinvestigated. Since this treatment as well as performic acid and incubation with anhydrous trifluoroacetic acid, caused a complete inactivation of LH-RH/FSH-RH, tryptophan residue is thought to be essential for the biological activity of this polypeptide.

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -

On the tryptophan residue in porcine LH and FSH-releasing hormone

Abstract

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