Abstract
The effect of 2-hydroxy-5-nitrobenzyl bromide on the biological activity of a preparation of pure porcine LH and FSH-releasing hormone (LH-RH/FSH-RH) was reinvestigated. Since this treatment as well as performic acid and incubation with anhydrous trifluoroacetic acid, caused a complete inactivation of LH-RH/FSH-RH, tryptophan residue is thought to be essential for the biological activity of this polypeptide.
| Original language | English |
|---|---|
| Pages (from-to) | 483-487 |
| Number of pages | 5 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 45 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 15 1971 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
On the tryptophan residue in porcine LH and FSH-releasing hormone. / Baba, Yoshihiko; Arimura, Akira; Schally, Andrew V.
In: Biochemical and Biophysical Research Communications, Vol. 45, No. 2, 15.10.1971, p. 483-487.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - On the tryptophan residue in porcine LH and FSH-releasing hormone
AU - Baba, Yoshihiko
AU - Arimura, Akira
AU - Schally, Andrew V
PY - 1971/10/15
Y1 - 1971/10/15
N2 - The effect of 2-hydroxy-5-nitrobenzyl bromide on the biological activity of a preparation of pure porcine LH and FSH-releasing hormone (LH-RH/FSH-RH) was reinvestigated. Since this treatment as well as performic acid and incubation with anhydrous trifluoroacetic acid, caused a complete inactivation of LH-RH/FSH-RH, tryptophan residue is thought to be essential for the biological activity of this polypeptide.
AB - The effect of 2-hydroxy-5-nitrobenzyl bromide on the biological activity of a preparation of pure porcine LH and FSH-releasing hormone (LH-RH/FSH-RH) was reinvestigated. Since this treatment as well as performic acid and incubation with anhydrous trifluoroacetic acid, caused a complete inactivation of LH-RH/FSH-RH, tryptophan residue is thought to be essential for the biological activity of this polypeptide.
UR - http://www.scopus.com/inward/record.url?scp=0015227404&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015227404&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(71)90844-8
DO - 10.1016/0006-291X(71)90844-8
M3 - Article
C2 - 4946275
AN - SCOPUS:0015227404
VL - 45
SP - 483
EP - 487
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -