On the potential role of proopiomelanocortin in skin physiology and pathology

Andrzej Slominski, Ralf Paus, Jacobo Wortsman

Research output: Contribution to journalArticle

117 Scopus citations

Abstract

Pro-opiomelanocortin (POMC) is the precursor of ACTH, α-MSH and β-endorphin, neuropeptides with multiple regulatory functions. Both the pituitary gland and peripheral tissues such as mammalian skin are capable of generating POMC-derived neuropeptides. Mammalian skin is also a target for POMC products; their possible roles in skin physiology and pathology are discussed in this communication.

Original languageEnglish (US)
Pages (from-to)C1-C6
JournalMolecular and Cellular Endocrinology
Volume93
Issue number1
DOIs
StatePublished - May 1993
Externally publishedYes

Keywords

  • Adrenocorticotropin
  • Endorphin
  • Melanotropin
  • Pro-opiomelanocortin
  • Skin
  • Stress

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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