On the opioid nature of phencyclidine and its 3-hydroxy derivative

Yossef Itzhak, Asher Kalir, Yosef Sarne

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Phencyclidine (PCP) and its 3-hydroxy derivative (PCP-3-OH) caused a dose-dependent, naloxone reversible inhibition of the response of the guinea pig ileum to electrical stimulation. Unlike PCP, PCP-3-OH exerted an opioid antagonistic effect in the mouse vas deferens bioassay. Whereas both compounds displayed a high affinity in displacing [3H]SKF-10047 binding to rat brain membranes, PCP-3-OH displayed a high affinity to [3H]morphine receptors also. The mediation of σ- and μ-receptors in the opioid effects of these drugs is discussed.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalEuropean Journal of Pharmacology
Volume73
Issue number2-3
DOIs
StatePublished - Jul 17 1981
Externally publishedYes

Fingerprint

Phencyclidine
Opioid Analgesics
Vas Deferens
mu Opioid Receptor
Opioid Receptors
Naloxone
Ileum
Biological Assay
Electric Stimulation
Guinea Pigs
Membranes
Brain
Pharmaceutical Preparations
3-hydroxyphencyclidine

Keywords

  • Opioid agonistic-antagonistic effect
  • Opioid receptors
  • Phencyclidine (PCP)

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

On the opioid nature of phencyclidine and its 3-hydroxy derivative. / Itzhak, Yossef; Kalir, Asher; Sarne, Yosef.

In: European Journal of Pharmacology, Vol. 73, No. 2-3, 17.07.1981, p. 229-233.

Research output: Contribution to journalArticle

Itzhak, Yossef ; Kalir, Asher ; Sarne, Yosef. / On the opioid nature of phencyclidine and its 3-hydroxy derivative. In: European Journal of Pharmacology. 1981 ; Vol. 73, No. 2-3. pp. 229-233.
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