TY - JOUR
T1 - On the neural networks of empathy
T2 - A principal component analysis of an fMRI study
AU - Nomi, Jason S.
AU - Scherfeld, Dag
AU - Friederichs, Skara
AU - Schäfer, Ralf
AU - Franz, Matthias
AU - Wittsack, Hans Jörg
AU - Azari, Nina P.
AU - Missimer, John
AU - Seitz, Rüdiger J.
PY - 2008/9/17
Y1 - 2008/9/17
N2 - Background: Human emotional expressions serve an important communicatory role allowing the rapid transmission of valence information among individuals. We aimed at exploring the neural networks mediating the recognition of and empathy with human facial expressions of emotion. Methods: A principal component analysis was applied to event-related functional magnetic imaging (fMRI) data of 14 right-handed healthy volunteers (29 +/- 6 years). During scanning, subjects viewed happy, sad and neutral face expressions in the following conditions: emotion recognition, empathizing with emotion, and a control condition of simple object detection. Functionally relevant principal components (PCs) were identified by planned comparisons at an alpha level of p < 0.001. Results: Four PCs revealed significant differences in variance patterns of the conditions, thereby revealing distinct neural networks: mediating facial identification (PC 1), identification of an expressed emotion (PC 2), attention to an expressed emotion (PC 12), and sense of an emotional state (PC 27). Conclusion: Our findings further the notion that the appraisal of human facial expressions involves multiple neural circuits that process highly differentiated cognitive aspects of emotion.
AB - Background: Human emotional expressions serve an important communicatory role allowing the rapid transmission of valence information among individuals. We aimed at exploring the neural networks mediating the recognition of and empathy with human facial expressions of emotion. Methods: A principal component analysis was applied to event-related functional magnetic imaging (fMRI) data of 14 right-handed healthy volunteers (29 +/- 6 years). During scanning, subjects viewed happy, sad and neutral face expressions in the following conditions: emotion recognition, empathizing with emotion, and a control condition of simple object detection. Functionally relevant principal components (PCs) were identified by planned comparisons at an alpha level of p < 0.001. Results: Four PCs revealed significant differences in variance patterns of the conditions, thereby revealing distinct neural networks: mediating facial identification (PC 1), identification of an expressed emotion (PC 2), attention to an expressed emotion (PC 12), and sense of an emotional state (PC 27). Conclusion: Our findings further the notion that the appraisal of human facial expressions involves multiple neural circuits that process highly differentiated cognitive aspects of emotion.
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U2 - 10.1186/1744-9081-4-41
DO - 10.1186/1744-9081-4-41
M3 - Article
C2 - 18798977
AN - SCOPUS:53949117358
VL - 4
JO - Behavioral and Brain Functions
JF - Behavioral and Brain Functions
SN - 1744-9081
M1 - 41
ER -