On the neural networks of empathy: A principal component analysis of an fMRI study

Jason S. Nomi, Dag Scherfeld, Skara Friederichs, Ralf Schäfer, Matthias Franz, Hans Jörg Wittsack, Nina P. Azari, John Missimer, Rüdiger J. Seitz

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Background: Human emotional expressions serve an important communicatory role allowing the rapid transmission of valence information among individuals. We aimed at exploring the neural networks mediating the recognition of and empathy with human facial expressions of emotion. Methods: A principal component analysis was applied to event-related functional magnetic imaging (fMRI) data of 14 right-handed healthy volunteers (29 +/- 6 years). During scanning, subjects viewed happy, sad and neutral face expressions in the following conditions: emotion recognition, empathizing with emotion, and a control condition of simple object detection. Functionally relevant principal components (PCs) were identified by planned comparisons at an alpha level of p < 0.001. Results: Four PCs revealed significant differences in variance patterns of the conditions, thereby revealing distinct neural networks: mediating facial identification (PC 1), identification of an expressed emotion (PC 2), attention to an expressed emotion (PC 12), and sense of an emotional state (PC 27). Conclusion: Our findings further the notion that the appraisal of human facial expressions involves multiple neural circuits that process highly differentiated cognitive aspects of emotion.

Original languageEnglish (US)
Article number41
JournalBehavioral and Brain Functions
Volume4
DOIs
StatePublished - Sep 17 2008
Externally publishedYes

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Biological Psychiatry
  • Behavioral Neuroscience

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    Nomi, J. S., Scherfeld, D., Friederichs, S., Schäfer, R., Franz, M., Wittsack, H. J., Azari, N. P., Missimer, J., & Seitz, R. J. (2008). On the neural networks of empathy: A principal component analysis of an fMRI study. Behavioral and Brain Functions, 4, [41]. https://doi.org/10.1186/1744-9081-4-41