On the nature of the hypothalamic substance which controls the secretion of ACTH

R. Guillemin; A. V. Schally

doi:10.1007/BF01243953

On the nature of the hypothalamic substance which controls the secretion of ACTH

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Abstract

Evidence for the existence of a specific substance (CRF) controlling the discharge of ACTH has been presented. The chromatographic mobilities of CRF activity are discussed is those of vasopressin, oxytocin, σ-and β-MSH, and ACTH. The possible existence of two types of molecules with CRF activity (σ-CRF and β-CRF) is discussed.

Original language	English (US)
Pages (from-to)	58-62
Number of pages	5
Journal	Acta Neurovegetativa
Volume	23
Issue number	1-2
DOIs	https://doi.org/10.1007/BF01243953
State	Published - Mar 1 1961
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)

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abstract = "Evidence for the existence of a specific substance (CRF) controlling the discharge of ACTH has been presented. The chromatographic mobilities of CRF activity are discussed is those of vasopressin, oxytocin, σ-and β-MSH, and ACTH. The possible existence of two types of molecules with CRF activity (σ-CRF and β-CRF) is discussed.",

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