On the memory of a chronic illness.

Pascal J. Goldschmidt-Clermont, Eric D. Peterson

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

The elderly are particularly susceptible to disease, yet the biological mechanisms that bring about this susceptibility remain unclear. Using atherosclerosis as a model chronic illness, we review how recent studies of bone marrow-derived vascular repair systems in mice and humans provide new insights into the causes and potential cures for age-related illness. Organisms are born with a finite capacity for stem cell-mediated repair after chronic exposure to tissue injury. Once that capacity is exhausted, a cycle of pathological inflammation ensues and leads to overt disease manifestations. Augmentation of stem cell-mediated repair systems may provide a novel means of treating or preventing many age-related illnesses.

Original languageEnglish (US)
Pages (from-to)re8
JournalScience of aging knowledge environment : SAGE KE
Volume2003
Issue number45
DOIs
StatePublished - Nov 12 2003

ASJC Scopus subject areas

  • Medicine(all)

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