On the memory of a chronic illness.

Pascal Goldschmidt-Clermont, Eric D. Peterson

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The elderly are particularly susceptible to disease, yet the biological mechanisms that bring about this susceptibility remain unclear. Using atherosclerosis as a model chronic illness, we review how recent studies of bone marrow-derived vascular repair systems in mice and humans provide new insights into the causes and potential cures for age-related illness. Organisms are born with a finite capacity for stem cell-mediated repair after chronic exposure to tissue injury. Once that capacity is exhausted, a cycle of pathological inflammation ensues and leads to overt disease manifestations. Augmentation of stem cell-mediated repair systems may provide a novel means of treating or preventing many age-related illnesses.

Original languageEnglish
JournalScience of aging knowledge environment : SAGE KE
Volume2003
Issue number45
StatePublished - Jan 1 2003
Externally publishedYes

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Chronic Disease
Stem Cells
Blood Vessels
Atherosclerosis
Bone Marrow
Inflammation
Wounds and Injuries

Cite this

Goldschmidt-Clermont, P., & Peterson, E. D. (2003). On the memory of a chronic illness. Science of aging knowledge environment : SAGE KE, 2003(45).

On the memory of a chronic illness. / Goldschmidt-Clermont, Pascal; Peterson, Eric D.

In: Science of aging knowledge environment : SAGE KE, Vol. 2003, No. 45, 01.01.2003.

Research output: Contribution to journalArticle

Goldschmidt-Clermont, P & Peterson, ED 2003, 'On the memory of a chronic illness.', Science of aging knowledge environment : SAGE KE, vol. 2003, no. 45.
Goldschmidt-Clermont P, Peterson ED. On the memory of a chronic illness. Science of aging knowledge environment : SAGE KE. 2003 Jan 1;2003(45).
Goldschmidt-Clermont, Pascal ; Peterson, Eric D. / On the memory of a chronic illness. In: Science of aging knowledge environment : SAGE KE. 2003 ; Vol. 2003, No. 45.
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