On the existence of cellular tocopheryl phosphate, its synthesis, degradation and cellular roles: A hypothesis

Yesim Negis, Jean Marc Zingg, Esra Ogru, Robert Gianello, Roksan Libinaki, Angelo Azzi

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

The finding that α-tocopheryl phosphate is present in cells in small amounts, that it can be synthesized and hydrolyzed supports the hypothesis that α-tocopheryl phosphate might be a signaling molecule. The possible pathways needed for the synthesis, hydrolysis and signaling are considered in this hypothesis as well the possible extension of this reaction to additional molecules such as tocopherols and tocotrienols. A possible mechanism of action of other tocopherol esters (succinate and maleate) is also hypothesized.

Original languageEnglish (US)
Pages (from-to)23-25
Number of pages3
JournalIUBMB life
Volume57
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

Keywords

  • α-tocopherol
  • α-tocopheryl phosphate
  • Cell signaling
  • Tocopherol esters
  • Vitamin E

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

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