On the crucial ventilatory setting adjustment from two- to one-lung ventilation

Halina C. Ferreira, Flavia Mazzoli-Rocha, Denise P. Momesso, Cristiane S.N.B. Garcia, Giovanna M.C. Carvalho, Roberta Soares, Luiz F.M. Prota, Marcelo M. Morales, Débora S. Faffe, Alysson R. Carvalho, Patricia R.M. Rocco, Walter A. Zin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Lung mechanics, histology, oxygenation and type-III procollagen (PCIII) mRNA were studied aiming to evaluate the need to readjust ventilatory pattern when going from two- to one-lung ventilation (OLV). Wistar rats were assigned to three groups: the left lung was not ventilated while the right lung received: (1) tidal volume (V T)=5ml/kg and positive end-expiratory pressure (PEEP)=2cm H 2O (V5P2), (2) V T=10ml/kg and PEEP=2cm H 2O (V10P2), and (3) V T=5ml/kg and PEEP=5cm H 2O (V5P5). At 1-h ventilation, V5P2 showed hypoxemia, alveolar collapse and impaired lung function. Higher PEEP minimized these changes and prevented hypoxemia. Although high V T prevented hypoxemia and maintained a higher specific compliance than V5P2, a morphologically inhomogeneous parenchyma and higher PCIII expression resulted. In conclusion, the association of low V T and an adequate PEEP level could be useful to maintain arterial oxygenation without inducing a possible inflammatory/remodeling response.

Original languageEnglish (US)
Pages (from-to)198-204
Number of pages7
JournalRespiratory Physiology and Neurobiology
Volume179
Issue number2-3
DOIs
StatePublished - Dec 15 2011
Externally publishedYes

Fingerprint

One-Lung Ventilation
Positive-Pressure Respiration
Lung
Collagen Type III
Pulmonary Atelectasis
Tidal Volume
Mechanics
Compliance
Ventilation
Wistar Rats
Histology
Messenger RNA
Hypoxia

Keywords

  • Extracellular matrix expression
  • One-lung ventilation
  • Procollagen type-III
  • Protective ventilator strategies
  • Shear stress
  • VILI

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Ferreira, H. C., Mazzoli-Rocha, F., Momesso, D. P., Garcia, C. S. N. B., Carvalho, G. M. C., Soares, R., ... Zin, W. A. (2011). On the crucial ventilatory setting adjustment from two- to one-lung ventilation. Respiratory Physiology and Neurobiology, 179(2-3), 198-204. https://doi.org/10.1016/j.resp.2011.08.006

On the crucial ventilatory setting adjustment from two- to one-lung ventilation. / Ferreira, Halina C.; Mazzoli-Rocha, Flavia; Momesso, Denise P.; Garcia, Cristiane S.N.B.; Carvalho, Giovanna M.C.; Soares, Roberta; Prota, Luiz F.M.; Morales, Marcelo M.; Faffe, Débora S.; Carvalho, Alysson R.; Rocco, Patricia R.M.; Zin, Walter A.

In: Respiratory Physiology and Neurobiology, Vol. 179, No. 2-3, 15.12.2011, p. 198-204.

Research output: Contribution to journalArticle

Ferreira, HC, Mazzoli-Rocha, F, Momesso, DP, Garcia, CSNB, Carvalho, GMC, Soares, R, Prota, LFM, Morales, MM, Faffe, DS, Carvalho, AR, Rocco, PRM & Zin, WA 2011, 'On the crucial ventilatory setting adjustment from two- to one-lung ventilation', Respiratory Physiology and Neurobiology, vol. 179, no. 2-3, pp. 198-204. https://doi.org/10.1016/j.resp.2011.08.006
Ferreira, Halina C. ; Mazzoli-Rocha, Flavia ; Momesso, Denise P. ; Garcia, Cristiane S.N.B. ; Carvalho, Giovanna M.C. ; Soares, Roberta ; Prota, Luiz F.M. ; Morales, Marcelo M. ; Faffe, Débora S. ; Carvalho, Alysson R. ; Rocco, Patricia R.M. ; Zin, Walter A. / On the crucial ventilatory setting adjustment from two- to one-lung ventilation. In: Respiratory Physiology and Neurobiology. 2011 ; Vol. 179, No. 2-3. pp. 198-204.
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