On the crucial ventilatory setting adjustment from two- to one-lung ventilation

Halina C. Ferreira, Flavia Mazzoli-Rocha, Denise P. Momesso, Cristiane S.N.B. Garcia, Giovanna M.C. Carvalho, Roberta M. Lassance-Soares, Luiz F.M. Prota, Marcelo M. Morales, Débora S. Faffe, Alysson R. Carvalho, Patricia R.M. Rocco, Walter A. Zin

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Lung mechanics, histology, oxygenation and type-III procollagen (PCIII) mRNA were studied aiming to evaluate the need to readjust ventilatory pattern when going from two- to one-lung ventilation (OLV). Wistar rats were assigned to three groups: the left lung was not ventilated while the right lung received: (1) tidal volume (V T)=5ml/kg and positive end-expiratory pressure (PEEP)=2cm H 2O (V5P2), (2) V T=10ml/kg and PEEP=2cm H 2O (V10P2), and (3) V T=5ml/kg and PEEP=5cm H 2O (V5P5). At 1-h ventilation, V5P2 showed hypoxemia, alveolar collapse and impaired lung function. Higher PEEP minimized these changes and prevented hypoxemia. Although high V T prevented hypoxemia and maintained a higher specific compliance than V5P2, a morphologically inhomogeneous parenchyma and higher PCIII expression resulted. In conclusion, the association of low V T and an adequate PEEP level could be useful to maintain arterial oxygenation without inducing a possible inflammatory/remodeling response.

Original languageEnglish (US)
Pages (from-to)198-204
Number of pages7
JournalRespiratory Physiology and Neurobiology
Issue number2-3
StatePublished - Dec 15 2011
Externally publishedYes


  • Extracellular matrix expression
  • One-lung ventilation
  • Procollagen type-III
  • Protective ventilator strategies
  • Shear stress
  • VILI

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine


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