On-demand use of erectile aids in men with preoperative erectile dysfunction treated by whole gland prostate cryoablation

M. Kimura, C. F. Donatucci, M. Tsivian, J. R. Caso, D. M. Moreira, V. Mouraviev, T. Satoh, S. Baba, T. J. Polascik

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Prostate cryoablation is an established minimally invasive treatment for localized prostate cancer (PCa). However, the impairment of erectile function (EF) is considered a serious complication of the procedure. To investigate the efficacy of erectile aids following cryotherapy, 93 patients who underwent whole gland prostate cryoablation with required complete medical records were analyzed. The changes in postoperative EF were evaluated using the International Index of Erectile Function (IIEF-5) questionnaire. Additionally, independent factors that could have a correlation to the postoperative IIEF-5 score or postoperative Expanded Prostate Cancer Index Composite (EPIC) score were assessed. In the entire cohort, the mean preoperative IIEF-5 score was 7.0±6.2. A total of 72 (77.4%) patients had moderate-to-severe preoperative erectile dysfunction. In longitudinal investigation, the patients using erectile aids showed the ability to recover to baseline after 24 months from cryoablation compared with the patients not using erectile aids. There were significant differences of IIEF-5 scores between these groups at 24 months (7.5 vs 3.0; P=0.025) and 36 months (8.5 vs 3.5; P<0.010). In multivariate analysis, the use of erectile aids correlated with restoration of IIEF-5 scores (odds ratio, 5.11; confidence interval (CI), 1.87-13.96; P=0.001) and lower EPIC sexual bother (coef, 19.61; CI, 0.32-38.89; P=0.046). Our data indicate that on-demand use of erectile aids could help restore EF and reduce sexual bother after whole gland prostate cryoablation. Although, erectile aids could not play a role as an adequate treatment for ED after whole gland prostate cryoablation, these results may aid in the decision-making process for PCa patients with preoperative and postoperative ED who have concern about sexual health-related quality of life.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalInternational Journal of Impotence Research
Volume23
Issue number2
DOIs
StatePublished - Mar 1 2011

Fingerprint

Cryosurgery
Erectile Dysfunction
Prostate
Prostatic Neoplasms
Confidence Intervals
Cryotherapy
Aptitude
Reproductive Health
Medical Records
Decision Making
Multivariate Analysis
Odds Ratio
Quality of Life
Therapeutics

Keywords

  • cryoablation
  • ED
  • EPIC
  • HRQoL
  • IIEF
  • prostate cancer

ASJC Scopus subject areas

  • Urology

Cite this

Kimura, M., Donatucci, C. F., Tsivian, M., Caso, J. R., Moreira, D. M., Mouraviev, V., ... Polascik, T. J. (2011). On-demand use of erectile aids in men with preoperative erectile dysfunction treated by whole gland prostate cryoablation. International Journal of Impotence Research, 23(2), 49-55. https://doi.org/10.1038/ijir.2011.3

On-demand use of erectile aids in men with preoperative erectile dysfunction treated by whole gland prostate cryoablation. / Kimura, M.; Donatucci, C. F.; Tsivian, M.; Caso, J. R.; Moreira, D. M.; Mouraviev, V.; Satoh, T.; Baba, S.; Polascik, T. J.

In: International Journal of Impotence Research, Vol. 23, No. 2, 01.03.2011, p. 49-55.

Research output: Contribution to journalArticle

Kimura, M, Donatucci, CF, Tsivian, M, Caso, JR, Moreira, DM, Mouraviev, V, Satoh, T, Baba, S & Polascik, TJ 2011, 'On-demand use of erectile aids in men with preoperative erectile dysfunction treated by whole gland prostate cryoablation', International Journal of Impotence Research, vol. 23, no. 2, pp. 49-55. https://doi.org/10.1038/ijir.2011.3
Kimura, M. ; Donatucci, C. F. ; Tsivian, M. ; Caso, J. R. ; Moreira, D. M. ; Mouraviev, V. ; Satoh, T. ; Baba, S. ; Polascik, T. J. / On-demand use of erectile aids in men with preoperative erectile dysfunction treated by whole gland prostate cryoablation. In: International Journal of Impotence Research. 2011 ; Vol. 23, No. 2. pp. 49-55.
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abstract = "Prostate cryoablation is an established minimally invasive treatment for localized prostate cancer (PCa). However, the impairment of erectile function (EF) is considered a serious complication of the procedure. To investigate the efficacy of erectile aids following cryotherapy, 93 patients who underwent whole gland prostate cryoablation with required complete medical records were analyzed. The changes in postoperative EF were evaluated using the International Index of Erectile Function (IIEF-5) questionnaire. Additionally, independent factors that could have a correlation to the postoperative IIEF-5 score or postoperative Expanded Prostate Cancer Index Composite (EPIC) score were assessed. In the entire cohort, the mean preoperative IIEF-5 score was 7.0±6.2. A total of 72 (77.4{\%}) patients had moderate-to-severe preoperative erectile dysfunction. In longitudinal investigation, the patients using erectile aids showed the ability to recover to baseline after 24 months from cryoablation compared with the patients not using erectile aids. There were significant differences of IIEF-5 scores between these groups at 24 months (7.5 vs 3.0; P=0.025) and 36 months (8.5 vs 3.5; P<0.010). In multivariate analysis, the use of erectile aids correlated with restoration of IIEF-5 scores (odds ratio, 5.11; confidence interval (CI), 1.87-13.96; P=0.001) and lower EPIC sexual bother (coef, 19.61; CI, 0.32-38.89; P=0.046). Our data indicate that on-demand use of erectile aids could help restore EF and reduce sexual bother after whole gland prostate cryoablation. Although, erectile aids could not play a role as an adequate treatment for ED after whole gland prostate cryoablation, these results may aid in the decision-making process for PCa patients with preoperative and postoperative ED who have concern about sexual health-related quality of life.",
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