Olfactory-Specific Quality of Life Outcomes after Endoscopic Endonasal Surgery of the Sella

Milap D. Raikundalia, Ryan J. Huang, Lyndon Chan, Tracy Truong, Maragatha Kuchibhatla, James Merchant, Ralph Abi Hachem, Patrick J. Codd, Ali R. Zomorodi, Jordan I. Teitelbaum, Bradley J. Goldstein, David W. Jang

Research output: Contribution to journalArticlepeer-review


Objective: To assess olfactory outcomes as measured by an olfactory-specific quality of life (QOL) questionnaire in patients undergoing EESBS for sellar lesions. Design: Retrospective case series. Setting: Tertiary academic medical center. Participants: In total, 36 patients undergoing EESBS for lesions limited to the sella were evaluated. Main Outcome Measures: The following were performed before and three months after surgery: 22-Item Sinonasal Outcomes Test (SNOT-22), University of Pennsylvania Smell Identification Test (UPSIT), and the Assessment of Self-reported Olfactory Functioning (ASOF), which has three domains: subjective olfactory capability scale (SOC), smell-related problems (SRP), and olfactory-related quality of life (ORQ). Results: Median age at surgery was 52.5 years, with a median tumor size of 1.8 cm (range: 0.2 to 3.9 cm). Pre- and postoperative median scores were 35 [34, 36.2] and 34.5 [32, 36] for UPSIT, 21 [7.5, 33.5] and 21.5 [6.8, 35.7] for SNOT-22, 10 [9, 10] and 9 [8, 10] for ASOF-SOC, 5 [4.8, 5] and 4.5 [4, 5] for ASOF-SRP, and 5 [5, 5] and 5 [4.5, 5] for ASOF-ORQ. There was no significant change in the two of the three domains of the ASOF. Correlation between ASOF and UPSIT scores were weak. Older age and larger tumor size were associated with worsened olfaction after surgery. Conclusions: Patients did not experience significant changes in olfactory-specific QOL three months after EESBS, as measured by two domains of the ASOF. The ASOF may serve as a useful adjunctive tool for assessing olfaction after surgery. The lack of correlation between UPSIT and ASOF suggests the need for more research in subjective olfactory-related quality of life after surgery.

Original languageEnglish (US)
JournalAllergy and Rhinology
StatePublished - 2021
Externally publishedYes


  • endoscopic minimally invasive surgery of the skull base
  • olfaction
  • quality of life

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology


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