Olfactory receptor OR2AT4 regulates human hair growth

Jérémy Chéret, Marta Bertolini, Leslie Ponce, Janin Lehmann, Teresa Tsai, Majid Alam, Hanns Hatt, Ralf Paus

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Olfactory receptors are expressed by different cell types throughout the body and regulate physiological cell functions beyond olfaction. In particular, the olfactory receptor OR2AT4 has been shown to stimulate keratinocyte proliferation in the skin. Here, we show that the epithelium of human hair follicles, particularly the outer root sheath, expresses OR2AT4, and that specific stimulation of OR2AT4 by a synthetic sandalwood odorant (Sandalore®) prolongs human hair growth ex vivo by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF-1. In contrast, co-administration of the specific OR2AT4 antagonist Phenirat® and silencing of OR2AT4 inhibit hair growth. Together, our study identifies that human hair follicles can engage in olfactory receptor-dependent chemosensation and require OR2AT4-mediated signaling to sustain their growth, suggesting that olfactory receptors may serve as a target in hair loss therapy.

Original languageEnglish (US)
Article number3624
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018
Externally publishedYes

Fingerprint

Odorant Receptors
hair
Hair
Hair Follicle
Growth
Santalum
Smell
Alopecia
Insulin-Like Growth Factor I
Keratinocytes
epithelium
apoptosis
Intercellular Signaling Peptides and Proteins
Skin
cells
stimulation
Epithelium
sheaths
Apoptosis
therapy

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Chéret, J., Bertolini, M., Ponce, L., Lehmann, J., Tsai, T., Alam, M., ... Paus, R. (2018). Olfactory receptor OR2AT4 regulates human hair growth. Nature Communications, 9(1), [3624]. https://doi.org/10.1038/s41467-018-05973-0

Olfactory receptor OR2AT4 regulates human hair growth. / Chéret, Jérémy; Bertolini, Marta; Ponce, Leslie; Lehmann, Janin; Tsai, Teresa; Alam, Majid; Hatt, Hanns; Paus, Ralf.

In: Nature Communications, Vol. 9, No. 1, 3624, 01.12.2018.

Research output: Contribution to journalArticle

Chéret, J, Bertolini, M, Ponce, L, Lehmann, J, Tsai, T, Alam, M, Hatt, H & Paus, R 2018, 'Olfactory receptor OR2AT4 regulates human hair growth', Nature Communications, vol. 9, no. 1, 3624. https://doi.org/10.1038/s41467-018-05973-0
Chéret J, Bertolini M, Ponce L, Lehmann J, Tsai T, Alam M et al. Olfactory receptor OR2AT4 regulates human hair growth. Nature Communications. 2018 Dec 1;9(1). 3624. https://doi.org/10.1038/s41467-018-05973-0
Chéret, Jérémy ; Bertolini, Marta ; Ponce, Leslie ; Lehmann, Janin ; Tsai, Teresa ; Alam, Majid ; Hatt, Hanns ; Paus, Ralf. / Olfactory receptor OR2AT4 regulates human hair growth. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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