Olfactory ensheathing glia: Their application to spinal cord regeneration and remyelination strategies

N. Kleitman, Mary B Bunge

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Grafts of peripheral nerves or peripheral nervous system (PNS) Schwann cells were among the first successful strategies applied to promote regeneration in the central nervous system (CNS). However, glial cells of the PNS and CNS (Schwann cells and astrocytes, respectively) establish borders where they meet, preventing functional reconnection between regenerating axons and CNS targets. Olfactory ensheathing glia (OEG) are cells that share characteristics with both Schwann cells and astrocytes and support the growth of olfactory nerve axons into the CNS throughout life. Application of these cells to promote regeneration and remyelination in the spinal cord is reviewed.

Original languageEnglish
Pages (from-to)65-81
Number of pages17
JournalTopics in Spinal Cord Injury Rehabilitation
Volume6
Issue number2
StatePublished - Jan 1 2000

Fingerprint

Spinal Cord Regeneration
Neuroglia
Schwann Cells
Central Nervous System
Peripheral Nervous System
Astrocytes
Axons
Regeneration
Olfactory Nerve
Peripheral Nerves
Spinal Cord
Transplants
Growth

Keywords

  • Astrocyte
  • Autotransplantation
  • Demyelination
  • Dorsal root entry zone
  • Myelin
  • Olfactory ensheathing glia
  • Regeneration
  • Schwann cells
  • Spinal cord injury
  • Transplantation

ASJC Scopus subject areas

  • Clinical Neurology
  • Rehabilitation

Cite this

Olfactory ensheathing glia : Their application to spinal cord regeneration and remyelination strategies. / Kleitman, N.; Bunge, Mary B.

In: Topics in Spinal Cord Injury Rehabilitation, Vol. 6, No. 2, 01.01.2000, p. 65-81.

Research output: Contribution to journalArticle

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