Olfactory ensheathing glia: Their application to spinal cord regeneration and remyelination strategies

N. Kleitman, M. B. Bunge

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Grafts of peripheral nerves or peripheral nervous system (PNS) Schwann cells were among the first successful strategies applied to promote regeneration in the central nervous system (CNS). However, glial cells of the PNS and CNS (Schwann cells and astrocytes, respectively) establish borders where they meet, preventing functional reconnection between regenerating axons and CNS targets. Olfactory ensheathing glia (OEG) are cells that share characteristics with both Schwann cells and astrocytes and support the growth of olfactory nerve axons into the CNS throughout life. Application of these cells to promote regeneration and remyelination in the spinal cord is reviewed.

Original languageEnglish (US)
Pages (from-to)65-81
Number of pages17
JournalTopics in Spinal Cord Injury Rehabilitation
Volume6
Issue number2
DOIs
StatePublished - Jan 1 2000

Keywords

  • Astrocyte
  • Autotransplantation
  • Demyelination
  • Dorsal root entry zone
  • Myelin
  • Olfactory ensheathing glia
  • Regeneration
  • Schwann cells
  • Spinal cord injury
  • Transplantation

ASJC Scopus subject areas

  • Clinical Neurology
  • Rehabilitation

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