OKI, injection adjustable keratoplasty: Biocompatibility and stability

I. Riss, C. Diemer, P. Hostyn, F. Leger, M. J.I.E. Rebeller, J. M. Parel

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Abstract

Purpose : GIAK is a new experimental surgical technique lor the correction of myopia. We analysed its stability in rabbits for six months with the corneal topograph EYEMAP KH-290. An histological analysis was performed at the end of the study. Methods : once a month, we analysed the topographies of the operated corneas (right eye) of 5 males and 5 females from day 1 to day 180. We also analysed the fellow eye from day 45 to day 180. Microscopy examination after HES staining, ultrastructural microscopy and immunohistochemistry were performed on the operated corneas alter 6 months to assess the biocompatibility of the hydrogel. Results : the topographical analysis of the non-operated corneas showed a continuous flattening with time. The flattening of the operated corneas was more important in the females than in the males. Six months after the injection, corneas were clear without any haze but multinucleated foreign body giant cells were present in all cases around the polyethylene oxide gel. Conclusions : GIAK seemed to be stable with time. We observed neither acute inflammation nor stromal neovascularisation but a granulomatous reaction to the polyethylene oxide gel.

Original languageEnglish (US)
Pages (from-to)S539
JournalInvestigative Ophthalmology and Visual Science
Volume38
Issue number4
StatePublished - Dec 1 1997

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ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Riss, I., Diemer, C., Hostyn, P., Leger, F., Rebeller, M. J. I. E., & Parel, J. M. (1997). OKI, injection adjustable keratoplasty: Biocompatibility and stability. Investigative Ophthalmology and Visual Science, 38(4), S539.