Oestrogen and progesterone receptors in Nigerian breast cancer

relationship to tumour histopathology and survival of patients.

Offiong Ikpatt, R. Ndoma-Egba

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

BACKGROUND: Expression of oestrogen receptors (ER) and progesterone receptors (PR) in breast carcinomas identifies patients that are more likely to respond to adjuvant therapy. OBJECTIVES: Our aim was to evaluate the prevalence and prognostic value of histologically confirmed ER and PR immunoreactivity in breast carcinoma seen at Calabar, Nigeria. DESIGN: Cross sectional study. SETTING: University of Calabar Teaching Hospital, Nigeria. SUBJECT: Sections of formalin-fixed, paraffin-embedded samples from 129 breast carcinomas were immunostained for ER and PR. RESULTS: ER and PR were immunohistochemically detected in 24.0% and 13.9%, respectively, of the breast carcinomas. The staining results were significantly associated, though negatively, with the axillary lymph node status, clinical stage, and histological grade. In survival analysis of the whole material, neither ER nor PR positivity showed any prognostic value. In the premenopausal group, both ER and PR showed a prognostic potential. However, they had no independent prognostic value. CONCLUSION: Further studies to assess the frequency and prognostic values of these hormone receptors in breast cancers, after standardized processing and a longer follow up period may be necessary to validate these findings. Furthermore, a consensus must be developed for scoring and reporting ER/PR in Nigerian material.

Original languageEnglish
Pages (from-to)122-126
Number of pages5
JournalThe Central African journal of medicine
Volume49
Issue number11-12
StatePublished - Nov 1 2003
Externally publishedYes

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Progesterone Receptors
Estrogen Receptors
Breast Neoplasms
Survival
Neoplasms
Nigeria
Survival Analysis
Teaching Hospitals
Paraffin
Formaldehyde
Cross-Sectional Studies
Lymph Nodes
Hormones
Staining and Labeling

ASJC Scopus subject areas

  • Medicine(all)
  • Infectious Diseases

Cite this

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title = "Oestrogen and progesterone receptors in Nigerian breast cancer: relationship to tumour histopathology and survival of patients.",
abstract = "BACKGROUND: Expression of oestrogen receptors (ER) and progesterone receptors (PR) in breast carcinomas identifies patients that are more likely to respond to adjuvant therapy. OBJECTIVES: Our aim was to evaluate the prevalence and prognostic value of histologically confirmed ER and PR immunoreactivity in breast carcinoma seen at Calabar, Nigeria. DESIGN: Cross sectional study. SETTING: University of Calabar Teaching Hospital, Nigeria. SUBJECT: Sections of formalin-fixed, paraffin-embedded samples from 129 breast carcinomas were immunostained for ER and PR. RESULTS: ER and PR were immunohistochemically detected in 24.0{\%} and 13.9{\%}, respectively, of the breast carcinomas. The staining results were significantly associated, though negatively, with the axillary lymph node status, clinical stage, and histological grade. In survival analysis of the whole material, neither ER nor PR positivity showed any prognostic value. In the premenopausal group, both ER and PR showed a prognostic potential. However, they had no independent prognostic value. CONCLUSION: Further studies to assess the frequency and prognostic values of these hormone receptors in breast cancers, after standardized processing and a longer follow up period may be necessary to validate these findings. Furthermore, a consensus must be developed for scoring and reporting ER/PR in Nigerian material.",
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N2 - BACKGROUND: Expression of oestrogen receptors (ER) and progesterone receptors (PR) in breast carcinomas identifies patients that are more likely to respond to adjuvant therapy. OBJECTIVES: Our aim was to evaluate the prevalence and prognostic value of histologically confirmed ER and PR immunoreactivity in breast carcinoma seen at Calabar, Nigeria. DESIGN: Cross sectional study. SETTING: University of Calabar Teaching Hospital, Nigeria. SUBJECT: Sections of formalin-fixed, paraffin-embedded samples from 129 breast carcinomas were immunostained for ER and PR. RESULTS: ER and PR were immunohistochemically detected in 24.0% and 13.9%, respectively, of the breast carcinomas. The staining results were significantly associated, though negatively, with the axillary lymph node status, clinical stage, and histological grade. In survival analysis of the whole material, neither ER nor PR positivity showed any prognostic value. In the premenopausal group, both ER and PR showed a prognostic potential. However, they had no independent prognostic value. CONCLUSION: Further studies to assess the frequency and prognostic values of these hormone receptors in breast cancers, after standardized processing and a longer follow up period may be necessary to validate these findings. Furthermore, a consensus must be developed for scoring and reporting ER/PR in Nigerian material.

AB - BACKGROUND: Expression of oestrogen receptors (ER) and progesterone receptors (PR) in breast carcinomas identifies patients that are more likely to respond to adjuvant therapy. OBJECTIVES: Our aim was to evaluate the prevalence and prognostic value of histologically confirmed ER and PR immunoreactivity in breast carcinoma seen at Calabar, Nigeria. DESIGN: Cross sectional study. SETTING: University of Calabar Teaching Hospital, Nigeria. SUBJECT: Sections of formalin-fixed, paraffin-embedded samples from 129 breast carcinomas were immunostained for ER and PR. RESULTS: ER and PR were immunohistochemically detected in 24.0% and 13.9%, respectively, of the breast carcinomas. The staining results were significantly associated, though negatively, with the axillary lymph node status, clinical stage, and histological grade. In survival analysis of the whole material, neither ER nor PR positivity showed any prognostic value. In the premenopausal group, both ER and PR showed a prognostic potential. However, they had no independent prognostic value. CONCLUSION: Further studies to assess the frequency and prognostic values of these hormone receptors in breast cancers, after standardized processing and a longer follow up period may be necessary to validate these findings. Furthermore, a consensus must be developed for scoring and reporting ER/PR in Nigerian material.

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