@article{e68aa863b6424b098fdc55cd43f006ed,
title = "Ocular Surface Pain: A Narrative Review",
abstract = "Ocular surface pain is a frequent cause of visits to an eye care providerand has a substantial impact on healthcare cost, yet a complete understanding of itscausative factors and tools for diagnostic workup are notably missing in many eyeclinics. The cornea has the densest sensory innervation in the human body and has thepotential to be a powerful producer of pain. Pain can manifest as a result of a noxiousstimulus or disruption in the ocular surface anatomy (nociceptive pain), or it canresult from abnormalities in the ocular surface neurosensory apparatus itself(neuropathic pain). Novel advances in neurobiology have sought to differentiate the twoentities, particularly to identify when chronic dry eye symptomatology is driven byneuropathic ocular pain. In this review, we seek to provide an overview of theprevalence, physiologic factors, and management of ocular surface paincomplaints.",
keywords = "Dry eye, Neuropathic pain, Nociceptive pain, Ocular pain, Ocular surface pain",
author = "Divy Mehra and Cohen, {Noah K.} and Anat Galor",
note = "Funding Information: This research was supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences Research I01 CX002015 (A. Galor), Biomedical Laboratory R&D (BLRD) Service I01 BX004893 (A. Galor), Department of Defense GW190010 (A. Galor), R01EY026174 (A. Galor), NIH Center Core Grant P30EY014801 and Research to Prevent Blindness Unrestricted Grant. No funding or sponsorship was received for the publication of this article. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. Divy Mehra, Noah K Cohen, and Anat Galor declare that they have no conflict of interest. This article is based on previously conducted studies and does not contain any studies with human participants or animals performed by any of the authors. Funding Information: This research was supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences Research I01 CX002015 (A. Galor), Biomedical Laboratory R&D (BLRD) Service I01 BX004893 (A. Galor), Department of Defense GW190010 (A. Galor), R01EY026174 (A. Galor), NIH Center Core Grant P30EY014801 and Research to Prevent Blindness Unrestricted Grant. No funding or sponsorship was received for the publication of this article. Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = sep,
day = "1",
doi = "10.1007/s40123-020-00263-9",
language = "English (US)",
volume = "9",
journal = "Ophthalmology and Therapy",
issn = "2193-8245",
publisher = "Springer London",
number = "3",
}