Ocular Surface Pain: A Narrative Review

Divy Mehra; Noah K. Cohen; Anat Galor

doi:10.1007/s40123-020-00263-9

Ocular Surface Pain: A Narrative Review

Divy Mehra, Noah K. Cohen, Anat Galor

Ophthalmology

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Ocular surface pain is a frequent cause of visits to an eye care providerand has a substantial impact on healthcare cost, yet a complete understanding of itscausative factors and tools for diagnostic workup are notably missing in many eyeclinics. The cornea has the densest sensory innervation in the human body and has thepotential to be a powerful producer of pain. Pain can manifest as a result of a noxiousstimulus or disruption in the ocular surface anatomy (nociceptive pain), or it canresult from abnormalities in the ocular surface neurosensory apparatus itself(neuropathic pain). Novel advances in neurobiology have sought to differentiate the twoentities, particularly to identify when chronic dry eye symptomatology is driven byneuropathic ocular pain. In this review, we seek to provide an overview of theprevalence, physiologic factors, and management of ocular surface paincomplaints.

Original language	English (US)
Journal	Ophthalmology and Therapy
Volume	9
Issue number	3
DOIs	https://doi.org/10.1007/s40123-020-00263-9
State	Published - Sep 1 2020

Keywords

Dry eye
Neuropathic pain
Nociceptive pain
Ocular pain
Ocular surface pain

ASJC Scopus subject areas

Ophthalmology

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10.1007/s40123-020-00263-9

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title = "Ocular Surface Pain: A Narrative Review",

abstract = "Ocular surface pain is a frequent cause of visits to an eye care providerand has a substantial impact on healthcare cost, yet a complete understanding of itscausative factors and tools for diagnostic workup are notably missing in many eyeclinics. The cornea has the densest sensory innervation in the human body and has thepotential to be a powerful producer of pain. Pain can manifest as a result of a noxiousstimulus or disruption in the ocular surface anatomy (nociceptive pain), or it canresult from abnormalities in the ocular surface neurosensory apparatus itself(neuropathic pain). Novel advances in neurobiology have sought to differentiate the twoentities, particularly to identify when chronic dry eye symptomatology is driven byneuropathic ocular pain. In this review, we seek to provide an overview of theprevalence, physiologic factors, and management of ocular surface paincomplaints.",

keywords = "Dry eye, Neuropathic pain, Nociceptive pain, Ocular pain, Ocular surface pain",

author = "Divy Mehra and Cohen, {Noah K.} and Anat Galor",

note = "Funding Information: This research was supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences Research I01 CX002015 (A. Galor), Biomedical Laboratory R&D (BLRD) Service I01 BX004893 (A. Galor), Department of Defense GW190010 (A. Galor), R01EY026174 (A. Galor), NIH Center Core Grant P30EY014801 and Research to Prevent Blindness Unrestricted Grant. No funding or sponsorship was received for the publication of this article. ",

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N2 - Ocular surface pain is a frequent cause of visits to an eye care providerand has a substantial impact on healthcare cost, yet a complete understanding of itscausative factors and tools for diagnostic workup are notably missing in many eyeclinics. The cornea has the densest sensory innervation in the human body and has thepotential to be a powerful producer of pain. Pain can manifest as a result of a noxiousstimulus or disruption in the ocular surface anatomy (nociceptive pain), or it canresult from abnormalities in the ocular surface neurosensory apparatus itself(neuropathic pain). Novel advances in neurobiology have sought to differentiate the twoentities, particularly to identify when chronic dry eye symptomatology is driven byneuropathic ocular pain. In this review, we seek to provide an overview of theprevalence, physiologic factors, and management of ocular surface paincomplaints.

AB - Ocular surface pain is a frequent cause of visits to an eye care providerand has a substantial impact on healthcare cost, yet a complete understanding of itscausative factors and tools for diagnostic workup are notably missing in many eyeclinics. The cornea has the densest sensory innervation in the human body and has thepotential to be a powerful producer of pain. Pain can manifest as a result of a noxiousstimulus or disruption in the ocular surface anatomy (nociceptive pain), or it canresult from abnormalities in the ocular surface neurosensory apparatus itself(neuropathic pain). Novel advances in neurobiology have sought to differentiate the twoentities, particularly to identify when chronic dry eye symptomatology is driven byneuropathic ocular pain. In this review, we seek to provide an overview of theprevalence, physiologic factors, and management of ocular surface paincomplaints.

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